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Hormone receptors in the aorta: why aneurysms hit men and women differently

NCT ID NCT05650892

Knowledge-focused Sponsor: Hanneke Takkenberg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Thoracic aortic aneurysms affect men more often than women, yet women face higher risks of dissection and death. Researchers are collecting aortic wall tissue from 30 adults undergoing elective aneurysm surgery to measure estrogen and testosterone receptor levels. The goal is to see whether differences in these receptors help explain why outcomes differ by sex, which could one day guide when surgery is recommended.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find clear sex differences in hormone receptor levels in the aortic wall, that could inform future guidelines on when to operate on men versus women.
What could go wrong
This is a small tissue study of 30 people, so it can only describe patterns, not prove cause or change treatment. Findings may not apply to patients with connective tissue diseases, who are excluded.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Feb 2021

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults (≥18 years old) who will undergo or already underwent elective surgery for thoracic aortic aneurysm at Erasmus MC, Rotterdam and LUMC, Leiden.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥ 18 years old) who have a thoracic aortic aneurysm and are scheduled for elective thoracic aortic surgery in the Erasmus MC or the LUMC. Exclusion Criteria: * Patients with a known connective tissue disease (e.g. Marfan Syndrome and Ehlers-Danlos syndromes). * Connective tissue disease,

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Conditions

The condition(s) this trial relates to.

thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thoracic aortic aneurysm

Contacts and locations

Locations

  • Erasmus MC

    Rotterdam, 3000 CA, Netherlands

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