Could this IV drug tame lupus kidney flares?

NCT ID NCT05138133

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This phase 3 study tests anifrolumab, an IV drug, against placebo in 359 adults with active lupus nephritis (kidney inflammation from lupus). The main goal is to see if more patients achieve complete kidney response, meaning better kidney function and less protein in urine. The trial also looks at reducing steroid use. It is active but not recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: anifrolumab (a drug given by IV infusion)
What this could lead to: If it works, this could offer a new treatment option for lupus nephritis, potentially improving kidney function and reducing the need for steroids.
What could go wrong: This is a phase 3 trial, but results are not yet final. The drug may not prove more effective than placebo, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

lupus nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS NEPHRITIS

Contacts and locations

Locations

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Glendale, Arizona, 85306, United States
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La Palma, California, 90623, United States
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Los Angeles, California, 90095, United States
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Upland, California, 91786, United States
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Plantation, Florida, 33324, United States
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Atlanta, Georgia, 30308, United States
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Louisville, Kentucky, 40202, United States
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Summit, New Jersey, 07901, United States
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Manhasset, New York, 11030, United States
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New York, New York, 10016, United States
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Winston-Salem, North Carolina, 27157, United States
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Middleburg Heights, Ohio, 44130, United States
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Colleyville, Texas, 76034, United States
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Edinburg, Texas, 78539, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77054, United States
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CABA, C1425EOE, Argentina
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Ciudad de Buenos Aires, C1015ABO, Argentina
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La Plata, 1900, Argentina
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Rosario, S2000PBJ, Argentina
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San Juan, 5400, Argentina
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Brussels, 1200, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Belo Horizonte, 30130 100, Brazil
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Campinas, 13087-567, Brazil
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Cuiabá, 78020-500, Brazil
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Maringá, 87060-040, Brazil
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Porto Alegre, 90035-903, Brazil
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Recife, 50740-465, Brazil
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Salvador, 40150-150, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04014-002, Brazil
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São Paulo, 04036-002, Brazil
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São Paulo, 05403-9000, Brazil
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Plovdiv, 4002, Bulgaria
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Sofia, 1431, Bulgaria
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Beijing, 100034, China
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Beijing, 100044, China
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Bengbu, 233004, China
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Chengdu, 610072, China
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Guangzhou, 510530, China
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Haikou, 570311, China
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Hangzhou, 310009, China
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Jinan, 250021, China
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Jining, 272011, China
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Nanchang, 330006, China
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Nanjing, 210009, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shengyang, 110004, China
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Shenzhen, 518036, China
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Shijiazhuang, 050001, China
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Tianjin, 300201, China
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Wuhan, 430060, China
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Wuxi, 214023, China
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Xi'an, 710061, China
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Zhengzhou, 450000, China
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Barranquilla, 080020, Colombia
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Medellín, 050010, Colombia
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Medellín, 050025, Colombia
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Aurillac, 15002, France
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Bordeaux, 33076, France
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Marseille, 13005, France
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Paris, 75013, France
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Paris, 75018, France
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Strasbourg, 67098, France
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Toulouse, 31059, France
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Cologne, 50937, Germany
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Dresden, 1307, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Kirchheim, 73230, Germany
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Mainz Am Rhein, 55131, Germany
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Budapest, 1085, Hungary
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Budapest, 1097, Hungary
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Debrecen, 4032, Hungary
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Ahmedabad, 380005, India
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Ahmedabad, 382421, India
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Dehradun, 248001, India
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Delhi, 110029, India
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Hyderabad, 500082, India
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Kolkata, 700020, India
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Nadiād, 387001, India
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Pune, 411001, India
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Secunderabad, 500003, India
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Vijayawada, 522002, India
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Visakapatnam, 530013, India
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Ancona, 60126, Italy
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Cona, 44124, Italy
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Eboli, 84025, Italy
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Padova, 35128, Italy
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Roma, 00161, Italy
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Bunkyō City, 113-8655, Japan
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Chiba, 260-8712, Japan
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Hiroshima, 734-8551, Japan
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Kita-gun, 761-0793, Japan
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Kitakyushu-shi, 807-8555, Japan
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Matsumoto-shi, 390-8621, Japan
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Nagasaki, 852-8501, Japan
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Okayama, 700-8558, Japan
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Ono, 675-1392, Japan
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Sagamihara-shi, 252-0375, Japan
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Sendai, 980-0872, Japan
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Shinagawa-ku, 142-0054, Japan
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Shinjuku-ku, 160-8582, Japan
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Shinjuku-ku, 162-8655, Japan
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Shinjuku-ku, 162-8666, Japan
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Toyoake-shi, 470-1192, Japan
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Batu Caves, 68100, Malaysia
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Ipoh, 30450, Malaysia
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Kajang, 43000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuantan, 25100, Malaysia
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Taiping, 34000, Malaysia
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Chihuahua City, 31000, Mexico
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Guadalajara, 44160, Mexico
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Guadalajara, 44650, Mexico
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México, 06726, Mexico
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México, 14080, Mexico
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San Luis Potosí City, 78290, Mexico
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Amsterdam, 1105 AZ, Netherlands
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Lima, 15023, Peru
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Lima, 15046, Peru
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Lima, 15102, Peru
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Lima, L34, Peru
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Lima, LIMA 27, Peru
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Lima, LIMA 29, Peru
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Lodz, 92-213, Poland
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Olsztyn, 10-561, Poland
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Opole, 46-020, Poland
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Poznan, 60-355, Poland
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Poznan, 61-545, Poland
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Rzeszów, 35-301, Poland
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Caguas, 00725, Puerto Rico
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Moscow, 115522, Russia
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Kaohsiung City, 833, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Taipei, 235, Taiwan
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Bangkok, 10220, Thailand
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Bangkok, 10330, Thailand
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Hat Yai, 90110, Thailand
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Muang, 50200, Thailand
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Ratchathewi, 10400, Thailand
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Adapazarı, 54290, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Istanbul, 34865, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, 35965, Turkey (Türkiye)
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Kahramanmaraş, 46100, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Hochiminh, 70000, Vietnam

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