New Alzheimer's drug aims to clear brain plaques

NCT ID NCT04639050

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the drug or a placebo to check safety and how well the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7126209 (Trontinemab)
What this could lead to: If successful, this could point toward a treatment that slows or stops Alzheimer's by clearing amyloid plaques from the brain.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMERS DISEASE

Contacts and locations

Locations

Abington Neurological Associates

Abington, Pennsylvania, 19001, United States
Advent Health Orlando

Orlando, Florida, 32804, United States
Alfred Hospital

Melbourne, Victoria, 3004, Australia
Alzheimer's Research and Treatment Center

Stuart, Florida, 34996, United States
Alzheimer's Research and Treatment Center - Columbus

Columbus, Georgia, 31904, United States
Alzheimer?s Research and Treatment Center

Wellington, Florida, 33414, United States
Center for Advanced Research & Education

Gainesville, Georgia, 30501, United States
Centro de Investigación Clínica UC-CICUC

Santiago, 8330034, Chile
Charter Research - Lady Lake/The Villages

The Villages, Florida, 32162, United States
Charter Research - Winter Park/Orlando

Orlando, Florida, 32803, United States
Conquest Research, LLC

Winter Park, Florida, 32789, United States
Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital

Tokyo, 190-8531, Japan
Fundación ACE

Barcelona, 08028, Spain
Heidelberg Repatriation Hospital

Heidelberg West, Victoria, 3081, Australia
Hospital Clinic i Provincial

Barcelona, 08036, Spain
Hospital Clinico Univ de Chile

Santiago, 8380456, Chile
Hospital General De Catalunya

Sant Cugat del Vallès, Barcelona, 8195, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Dr. Peset

Valencia, 46017, Spain
Hospital Universitario la Fe

Valencia, 46026, Spain
Inha University Hospital

Incheon, 22332, South Korea
JEM Research LLC

Atlantis, Florida, 33462, United States
K2 Medical Research - The Villages

Lady Lake, Florida, 32159, United States
K2 Medical Research, LLC

Maitland, Florida, 32751, United States
K2 Medical Research-Winter Garden

Clermont, Florida, 34711, United States
Keio University Hospital

Tokyo, 160-8582, Japan
Kerwin Research Center, LLC

Dallas, Texas, 75231, United States
Koseikai Takeda Hospital

Kyoto, 600-8558, Japan
NZOZ WCA

Wroc?aw, 53-659, Poland
National Hospital Organization Utano National Hospital

Kyoto, 616-8255, Japan
Optimus U Corp

Miami, Florida, 33135, United States
Osrodek Badan Klinicznych Euromedis

Szczecin, 70-111, Poland
Policlínica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
Richmond Clinical Trials

Richmond, British Columbia, V6V 2L1, Canada
Samsung Medical Center

Seoul, 06351, South Korea
Summit Research Network Inc.

Portland, Oregon, 97210, United States
Tokyo Metropolitan Institute for Geriatrics and Gerontology

Tokyo, 173-0015, Japan
Toronto Memory Program

Toronto, Ontario, M3B 2S7, Canada
UCL Institute of Neurology

London, WC1N 3BG, United Kingdom
Yokohama City Minato Red Cross Hospital

Kanagawa, 231-8682, Japan

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