New Alzheimer's drug aims to slow memory loss by targeting brain tangles

NCT ID NCT04619420

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an investigational drug called JNJ-63733657 can slow the progression of early Alzheimer's disease. The drug is an antibody designed to target and clear tau protein, one of the key abnormal proteins that builds up in the Alzheimer's brain. About 523 people with early-stage Alzheimer's will receive either the drug or a placebo for two years to see if it helps preserve memory and daily function.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AZ St.-Jan Brugge-Oostende AV

Bruges, 8000, Belgium
Advanced Memory Research Institute of NJ

Toms River, New Jersey, 08755, United States
Alexian Brothers Medical Center - Neuroscience Research Institute

Elk Grove Village, Illinois, 60007, United States
Algemeen Ziekenhuis Delta

Roeselare, 8800, Belgium
Alphab Global Research

Jupiter, Florida, 33458, United States
Alzheimers Research and Treatment Center

Wellington, Florida, 33414, United States
Anil Nair dba Alzheimer's Disease Center

Braintree, Massachusetts, 02184, United States
Aqualane Clinical Research

Naples, Florida, 34105, United States
Austin Health

Ivanhoe, 3079, Australia
Australian Alzheimer's Research Foundation Incorporated

Nedlands, 6009, Australia
Axiom Clinical Research of Florida

Tampa, Florida, 33609, United States
BRC - Amsterdam

Amsterdam, 1081 GN, Netherlands
BRC - Den Bosch

's-Hertogenbosch, 5223 LA, Netherlands
BRC Zwolle

Zwolle, 8052 AZ, Netherlands
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Box Hill Hospital

Box Hill, 3128, Australia
Brain Matters Research

Delray Beach, Florida, 33445, United States
Brown University School of Medicine

Providence, Rhode Island, 02906, United States
CHU Nantes - Hopital Nord Laënnec

Nantes, 44093, France
CHU Toulouse - Hôpital La Grave

Toulouse, 31059, France
Centro At. Esp. Oroitu

Algorta - Getxo, 48993, Spain
Charing Cross Hospital

London, W6 8RF, United Kingdom
Charter Research

The Villages, Florida, 32162, United States
Chu Rennes Hopital Pontchaillou

Rennes, 35009, France
Cleveland Clinic Lou Revo Center for Brain Health

Cleveland, Ohio, 44195, United States
ClinCloud Clinical Research

Viera, Florida, 32904, United States
Clinical NeuroScience Solutions Inc

Jacksonville, Florida, 32256, United States
Clinical Research Hospital Tokyo

Shinjuku-ku, 162-0053, Japan
Conquest Research

Winter Park, Florida, 32789, United States
Dignity Health

Phoenix, Arizona, 85013, United States
Fukuoka University Hospital

Fukuoka, 814-0180, Japan
Fund. Ace-Inst. Cat. Neuroc. Aplicades

Barcelona, 08028, Spain
Georgetown University Clinical Research Unit CRU

Washington D.C., District of Columbia, 20007, United States
Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States
HammondCare Neurodegenerative Clinical Trials - VIC

Malvern, 3144, Australia
Hattiesburg Clinic

Hattiesburg, Mississippi, 39401, United States
Himeji Central Hospital Clinic

Himeji, 672-8043, Japan
Hopital Charles Nicolle

Rouen, 76031, France
Hopital Lariboisiere-Fernand Widal

Paris, 75010, France
Hopital Pellegrin CHU Bordeaux

Bordeaux, 33076, France
Hopital Pitie Salpetriere

Paris, 75013, France
Hopital Roger Salengro - CHU Lille

Lille, 59037, France
Hosp. Clinico San Carlos

Madrid, 28040, Spain
Hosp. Del Mar

Barcelona, 08003, Spain
Hosp. Mutua Terrassa

Terrassa, 08221, Spain
Hosp. Univ. I Politecni La Fe

Valencia, 46026, Spain
Hosp. Univ. Santa Maria

Lleida, 25198, Spain
Hosp. de La Santa Creu I Sant Pau

Barcelona, 08025, Spain
Hôpital Bretonneau

Tours, 37000, France
Idc Salud Hosp. Gral. de Catalunya

Barcelona, 08195, Spain
Inage Neurology and Memory Clinic

Chiba, 263-0043, Japan
Indiana University

Indianapolis, Indiana, 46202, United States
Irvine Clinical Research

Irvine, California, 92614, United States
JEM Research LLC

Atlantis, Florida, 33462, United States
Jessa Ziekenhuis

Hasselt, 3500, Belgium
Jinsenkai MI Clinic

Toyonaka-shi, 5600004, Japan
K2 Medical Research

Maitland, Florida, 32751, United States
Karolinska Universitetssjukhuset

Stockholm, 14186, Sweden
Kawartha Centre - Redefining Healthy Aging

Peterborough, Ontario, K9H 2P4, Canada
Kawashima Neurology Clinic

Fujisawa-shi, 251-0038, Japan
Keikokai P-One Clinic

Hachiōji, 192-0071, Japan
Keystone Clinical Studies LLC

Plymouth Meeting, Pennsylvania, 19462, United States
Kobe City Medical Center General Hospital

Kobe, 650-0047, Japan
Koukan Clinic

Kawasaki, 210-0852, Japan
Kurume University Hospital

Kurume, 830-0011, Japan
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
McGill University

Montreal, Quebec, H3A 2B4, Canada
Memory Clinic Inc

Bennington, Vermont, 05201, United States
Merritt Island Medical Research, LLC

Merritt Island, Florida, 32952, United States
Miami Jewish Health System

Miami, Florida, 33137, United States
Nagomi Clinic

Toyonaka-shi, 560-0004, Japan
National Center For Geriatrics And Gerontology

Obu-shi, 474-8511, Japan
National Hospital Organization Hizen Psychiatric Center

Kanzaki-gun, 842-0192, Japan
Neuro Trials Victoria

Carlton, 3053, Australia
NeuroCognitive Institute

Mount Arlington, New Jersey, 07856, United States
Neurological Associates of Albany, PC

Albany, New York, 12208, United States
Neuropsychiatric Research Center of SWFL

Fort Myers, Florida, 33912, United States
New York University Medical Center

New York, New York, 10016, United States
Pacific Research Network Prn

San Diego, California, 92103, United States
Palm Beach Neurology and Premier Research Institute

West Palm Beach, Florida, 33407, United States
Parkwood Institute

London, Ontario, N6C 0A7, Canada
Princeton Medical Institute

Princeton, New Jersey, 08540, United States
QPS Netherlands

Leeuwarden, 8934AD, Netherlands
Rakuwakai Otowa Hospital

Kyoto, 607-8062, Japan
Rakuwakai Otowa Rehabilitation Hospital

Kyoto, 607-8113, Japan
Renstar Medical Research

Ocala, Florida, 34470, United States
Rijikai Medical Corporation Katayama Medical Clinic

Kurashiki-shi, 7100813, Japan
Royal Adelaide Hospital

Adelaide, 5000, Australia
Royal Melbourne Hospital

Parkville, 3050, Australia
Royal United Hospital

Bath, BA1 3NG, United Kingdom
Saiseikai Narashino Hospital

Narashino, 275-0006, Japan
Sandhill Research

Decatur, Georgia, 30030, United States
Sensible Healthcare

Ocoee, Florida, 34761, United States
Shonan Kamakura General Hospital

Kamakura-shi, 247-8533, Japan
Stanford University Medical Center

Palo Alto, California, 94304, United States
Stedman Clinical Trials

Tampa, Florida, 33613, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
Takeda General Hospital

Aizu-Wakamatsu, 965-8585, Japan
Tandem Intermediate LLC

Maitland, Florida, 32751, United States
The Emory Clinic

Atlanta, Georgia, 30329, United States
The University of Texas Health Science Center at Houston

Houston, Texas, 77054, United States
Tokyo Medical University Hospital

Tokyo, 160-0023, Japan
Tokyo Metropolitan Geriatric Hospital

Tokyo, 173-0015, Japan
Toronto Memory Program (Neurology Research Inc.)

Toronto, Ontario, M3B 257, Canada
UCL Hopital Saint-Luc

Brussels, 1200, Belgium
UHN-Toronto Western Hospital

Toronto, Ontario, M5T 2S8, Canada
UZ Antwerpen

Edegem, 2650, Belgium
UZ Brussel

Jette, 1090, Belgium
UZ Leuven

Leuven, 3000, Belgium
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
University of Alabama Birmingham

Birmingham, Alabama, 35233, United States
University of California - Los Angeles

Los Angeles, California, 90095, United States
University of California San Diego Medical Center

La Jolla, California, 92037, United States
University of Miami Miller School of Medicine

Miami, Florida, 33136, United States
University of South Florida - Health Byrd Alzheimer Institute

Tampa, Florida, 33613, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
Velocity Clinical Research

East Syracuse, New York, 13057, United States
Wake Forest Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School Of Medicine

St Louis, Missouri, 63110, United States
Wexner Medical Center at the Ohio State University

Columbus, Ohio, 43221, United States
Yale University School Of Medicine

New Haven, Connecticut, 06510, United States
Yokohama Brain and Spine Center

Yokohama, 235-0012, Japan

Conditions

Explore the condition pages connected to this study.

ALZHEIMER DISEASE COGNITIVE DYSFUNCTION DEMENTIA