Can a lung drug stop transplant rejection? new trial tests Alpha-1 antitrypsin for GVHD
NCT ID NCT03805789
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a drug called alpha-1 antitrypsin (AAT) can prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the patient's body. The trial enrolled 222 participants and compared AAT to a placebo. The goal was to see if AAT could delay or prevent severe GVHD and improve outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Alpha-1 antitrypsin (AAT)
What this could lead to
If it works, this could offer a new way to prevent graft-versus-host disease, a common and dangerous complication of stem cell transplants.
What could go wrong
This is a mid-stage trial with 222 participants, so results are not yet conclusive. The treatment may not reduce GVHD risk or could cause side effects like allergic reactions.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aichi Medical Center Nagoya Daiichi Hospital
Nagoya, 4538511, Japan
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Anjo Kosei Hospital
Anjo-shi, 4668602, Japan
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Ankara Abdurrahman Yurtaslan
Ankara, 06200, Turkey (Türkiye)
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27705, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
Calabria, 89133, Italy
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Hiroshima University Kasumi Campus
Hiroshima, 7348551, Japan
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Hokkaido University Hospital
Sapporo, 0608648, Japan
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HonorHealth Scottsdale Shea Medical Center
Scottsdale, Arizona, 85258, United States
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Hospital Universitario Valle de Hebron
Barcelona, 08035, Spain
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INJE University Haeundae Paik Hospital
Busan, 48108, South Korea
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Johns Hopkins Hospital
St. Petersburg, Florida, 33701, United States
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Marqués de Valdecilla University Hospital
Barcelona, 39008, Spain
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Nagoya University Hospital
Nagoya, 4668550, Japan
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Okayama University Hospital
Okayama, 71008558, Japan
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Osaka International Cancer Institute
Osaka, 5418567, Japan
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Osaka Metropolitan University Hospital
Osaka, 5458586, Japan
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Pusan National University Hospital
Busan, 49241, South Korea
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Royal Brisbane and Women's Hospital
Herston, Queenland, 4029, Australia
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Salamanca University Hospital
Salamanca, 37007, Spain
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Seoul National University Hospital
Seoul, 03080, South Korea
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The University of Texas-MD Anderson Cancer Center
San Antonio, Texas, 77030, United States
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Tokyo Metropolitan Komagome Hospital
Bunkyō City, 1138677, Japan
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Turgut Ozal Medicine Center
Battalgazi, 44280, Turkey (Türkiye)
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Uniklinik Köln
Cologne, 50937, Germany
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University Hospital Catania
Calabria, Catania, 95123, Italy
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University Hospital Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Kansas Cancer Center
Westwood, Kansas, 66205, United States
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University of Michigan Medical Center
Ann Arbor, Michigan, 48109, United States
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University of Utah Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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University of Virginia Health System
Charlottesville, Virginia, 22903, United States