Can a natural hormone rebuild the brain in Alzheimer's? new trial aims to find out.

NCT ID NCT04838301

First seen Mar 16, 2026 · Last updated Apr 28, 2026 · Updated 6 times

Summary

This study tests whether a natural hormone called allopregnanolone can safely slow or reverse brain shrinkage in people with early-stage Alzheimer's disease. About 100 men and postmenopausal women aged 55-80 will receive either the hormone or a placebo over several months. The main goal is to see if it protects the memory center of the brain and improves thinking skills.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • ATP Clinical Research

    RECRUITING

    Costa Mesa, California, 92626, United States

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-••••

    Contact

  • Combined Research Orlando

    TERMINATED

    Orlando, Florida, 32807, United States

  • Conquest Research

    RECRUITING

    Winter Park, Florida, 32789, United States

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-••••

    Contact

  • MedVadis Research

    RECRUITING

    Waltham, Massachusetts, 02451, United States

    Contact

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-••••

  • Miami Jewish Health

    RECRUITING

    Miami, Florida, 33137, United States

    Contact Phone: •••-•••-••••

    Contact

    Contact Phone: •••-•••-••••

  • Optimus U Corporation

    RECRUITING

    Miami, Florida, 33135, United States

    Contact

    Contact

  • Perseverance Research Center

    RECRUITING

    Scottsdale, Arizona, 85253, United States

    Contact

    Contact Phone: •••-•••-••••

  • Syrentis Clinical Research

    TERMINATED

    Santa Ana, California, 92705, United States

  • University of Arizona / Clinical & Translational Sciences Research Center

    RECRUITING

    Tucson, Arizona, 85721, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Wake Research-PRI, LLC

    WITHDRAWN

    Los Alamitos, California, 90720, United States

Conditions

Explore the condition pages connected to this study.