New drug cocktail targets tough lung cancer
NCT ID NCT07669779
First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times
Summary
This phase 2 trial tests a new drug called AK146D1, given together with other cancer drugs, in 348 people with advanced non-small cell lung cancer that cannot be surgically removed. The study aims to see if the combination is safe and can shrink tumors. Participants will receive the drugs by injection or infusion, and researchers will monitor side effects and how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AK146D1 (a bispecific antibody-drug conjugate targeting Trop2 and Nectin4) combined with AK112 (a bispecific antibody targeting PD-1 and VEGF) or other anticancer drugs
- What this could lead to
- If successful, this could provide a new treatment option for advanced non-small cell lung cancer that has not responded to other therapies.
- What could go wrong
- This is an early phase 2 trial, so the combination may not prove effective or safe enough for wider use. Side effects from the drug combination are possible and being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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SunYat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, China
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