Exercise may reverse chemo heart damage in childhood cancer survivors

NCT ID NCT04036032

Completed Disease control Sponsor: Connecticut Children's Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a 3-month aerobic exercise program could improve heart function in 47 childhood cancer survivors who had been treated with anthracycline chemotherapy. Participants chose their own exercise and received support at a YMCA. The goal was to see if exercise could reverse some of the heart damage caused by the chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aerobic exercise program
What this could lead to: If it works, this could point toward a simple, non-drug way to help protect the hearts of childhood cancer survivors who received certain chemotherapy.
What could go wrong: This is a small, completed study with only 47 participants, so results may not apply to everyone. Exercise may not reverse heart damage for all survivors.

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Conditions

The condition(s) this trial relates to.

cancer Cardiotoxicity childhood malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CARDIOTOXICITY

Contacts and locations

Locations

CT Children's Medical Center

Hartford, Connecticut, 06106, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

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