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Exercise may sharpen aging brains after depression

NCT ID NCT04670510

Completed Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether aerobic exercise can improve thinking skills and brain structure in older adults who have recovered from late-life depression. Forty-six participants aged 60 and older completed supervised exercise sessions over 6 months. Researchers measured changes in fitness, brain scans, and cognitive tests to see if exercise helps protect against dementia in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
aerobic exercise
What this could lead to
If successful, this could point toward a non-drug way to protect brain health and reduce dementia risk in older adults with a history of depression.
What could go wrong
This is a small, early-stage study with only 46 participants and no control group, so results may not be definitive or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Depression depressive disorder Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION IN OLD AGE

Contacts and locations

Locations

  • UPMC Western Psychiatric Hospital

    Pittsburgh, Pennsylvania, 15213, United States

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