Intra-Articular adrenaline versus tourniquet in knee arthroscopy in a tertiary care center: a prospective cohort study
NCT ID NCT07813715
First seen Sep 10, 2026 ยท Last updated Sep 10, 2026
Summary
Arthroscopy has become one of the most commonly performed orthopaedic surgeries in the world due to it being a minimally invasive technique. Clear visualization is crucial for both safe and efficient arthroscopic procedures. Pneumatic tourniquet has been widely used in knee arthroscopic surgeries to obtain bloodless surgical field, improve visualization, and thereby surgical time. However, complications from tourniquet use are not uncommon, particularly in patients whose procedure takes longer than 60 minutes. Using a tourniquet could increase problems, such as electromyographic alterations, nerve compressions, arterial occlusions, delayed muscle recovery, and muscle weakness. Intra-articular adrenaline injection creates a bloodless field by reducing local perfusion through its vasoconstrictive properties, mimicking the effect of a tourniquet. It appeared to be a potentially effective and safe option. Therefore, this study aimed to evaluate intra-articular adrenaline infiltration as an alternative for achieving a bloodless field without tourniquet-related side effects, in terms of clinical efficacy, operative duration and safety. We would compare intra operative visibility and safety of intra articular adrenaline (1:200,000) injections with use of a tourniquet in arthroscopic knee surgeries. Comparision is made between one group that received standard tourniquet application and another group that received intra articular adrenaline injection. Then the intraoperative visibility in these two groups is compared using tools like surgeon visual analogue score and amount of irrigation fluid required. The effectiveness and safety of the method used is compared using appropriate statistical tools. Null Hypothesis: There is no difference in intraoperative visibility and safety during knee arthroscopic surgeries with standard tourniquet application versus intraarticular adrenaline injection. H0: outcome in Adrenaline group =\< outcome in Tourniquet group Alternative Hypothesis: Intra articular adrenaline injection is better than tourniquet use in arthroscopic knee surgeries with respect to operative field visibility and safety. H1: outcome in Adrenaline group \> or (not less than) outcome in Tourniquet group
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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169 people
The number who actually took part.
- Started
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Jan 2023
- Finished
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Jul 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Patients who are skeletally matured (18 year and above) undergoing knee arthroscopic surgeries. The surgeries included are: * Anterior Cruciate Ligament reconstruction * Anterior Cruciate Ligament repair * Anterior Cruciate Ligament decompression * Meniscus repair surgeries * Meniscus resection surgeries - Patients who provide consent for the study Exclusion Criteria: * The patient with following procedures are excluded: * Posterior Cruciate Ligament (PCL) surgeries * Multi-ligament surgeries * Osteochondral or intra articular fractures * Patients under 18 years of age * Patients who do not provide consent
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dhulikhel Hospital, Kathmandu University Hospital
Dhulikhel, Bagmati, 45200, Nepal
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