New hope for early breast cancer: targeted therapy may replace chemo

NCT ID NCT06081244

Recruiting now Disease control Sponsor: West German Study Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This phase 3 trial is testing whether a targeted drug called sacituzumab govitecan (Trodelvy), alone or combined with the immunotherapy pembrolizumab (Keytruda), can effectively treat low-risk triple-negative breast cancer before surgery. The study aims to see if these drugs can eliminate the tumor better than standard chemotherapy. About 348 patients with early-stage, node-negative disease will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda)
What this could lead to: If successful, this could offer a more targeted, less toxic treatment option for early-stage triple-negative breast cancer, potentially improving cure rates without standard chemotherapy.
What could go wrong: This is an early-phase trial with a relatively small number of participants. The combination may not prove more effective than the single drug, and side effects from immunotherapy could be significant.

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Conditions

The condition(s) this trial relates to.

breast neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

AGAPLESION Markus Krankenhaus
RECRUITING

Frankfurt am Main, Hesse, 60431, Germany
Caritasklinikum Saarbrücken
ACTIVE_NOT_RECRUITING

Saarbrücken, Saarland, 66113, Germany
Charité Campus Mitte Universitätsklinikum Berlin
SUSPENDED

Berlin, State of Berlin, 10117, Germany
DBZ Onkologie GmbH
RECRUITING

Berlin, Brandenburg, 12623, Germany
Ev. Krankenhaus Berlin-Spandau
RECRUITING

Berlin, North Rhine-Westphalia, 13589, Germany
Ev. Krankenhaus Bethesda Brustzentrum Niederrhein
RECRUITING

Mönchengladbach, North Rhine-Westphalia, 41061, Germany
GRN Klinik Weinheim
RECRUITING

Weinheim, Baden-Württembergs, 69469, Germany
Gyn. Oncology Clinic Research UG
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40235, Germany
Gynäkologische Gemeinschaftspraxis-Ärztehaus am Bahnhofsplatz
RECRUITING

Hildesheim, Lower Saxony, 31134, Germany
Helios Universitätsklinikum Wuppertal Barmen
RECRUITING

Wuppertal, North Rhine-Westphalia, 42283, Germany
Hämatologie-Onkologie im Zentrum MVZ GmbH
RECRUITING

Augsburg, Bavaria, 86150, Germany
Hämatologisch/Onkologische Schwerpunktpraxis Bremen
RECRUITING

Bremen, Free Hanseatic City of Bremen, 28209, Germany
Johanniter GmbH Johanniter Krankenhaus Stendal
RECRUITING

Stendal, Sachsen-Anhalts, 39576, Germany
Kliniken Böblingen
RECRUITING

Böblingen, Baden-Wurttemberg, 71032, Germany
Kliniken Essen-Mitte
RECRUITING

Essen, North Rhine-Westphalia, 45136, Germany
Kliniken der Stadt Köln, Krankenhaus Holweide
RECRUITING

Cologne, North Rhine-Westphalia, 51067, Germany
Klinikum Bremerhaven Reinkenheide gGmbH
SUSPENDED

Bremerhaven, Free Hanseatic City of Bremen, 27574, Germany
Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, Saxony, 09116, Germany
Klinikum Ernst von Bergmann gGmbH
RECRUITING

Potsdam, Brandenburg, 14467, Germany
Klinikum Leverkusen gGmbH
RECRUITING

Leverkusen, North Rhine-Westphalia, 51375, Germany
Klinikum Mutterhaus-Trier
RECRUITING

Trier, Rhineland-Palatinate, 54290, Germany
Klinikum der Universität München
RECRUITING

München, München, 80336, Germany
MKS St.Paulus GmbH (ehem.Marienkrankenhaus)
RECRUITING

Schwerte, North Rhine-Westphalia, 58239, Germany
MVZ II der Niels Stensen Kliniken
RECRUITING

Georgsmarienhütte, Lower Saxony, 49124, Germany
MVZ MediaVita, St. Franziskus-Hospital Münster
RECRUITING

Münster, North Rhine-Westphalia, 48145, Germany
MVZ Medical Center Düsseldorf - GynOnco
TERMINATED

Düsseldorf, North Rhine-Westphalia, 40235, Germany
Mammazentrum Hamburg am Krankenhaus Jerusalem
RECRUITING

Hamburg, Free and Hanseatic City of Hamburg, 20357, Germany
Marien Hospital Witten
RECRUITING

Witten, North Rhine-Westphalia, 58452, Germany
Onkologische Schwerpunktpraxis Bielefeld
RECRUITING

Bielefeld, North Rhine-Westphalia, 33604, Germany
Praxis für interdisziplinäre Onkologie & Hämatologie
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79110, Germany
Praxisnetzwerk Hämatologie und Onkologie, Troisdorf
RECRUITING

Troisdorf, North Rhine-Westphalia, 53840, Germany
Rotkreuzklinikum München
ACTIVE_NOT_RECRUITING

München, Bavaria, 80637, Germany
SLK Kliniken Heilbronn, Frauenklinik
RECRUITING

Heilbronn, Baden-Wurttemberg, 74078, Germany
St. - Antonius - Hospital
RECRUITING

Eschweiler, North Rhine-Westphalia, 52249, Germany
St. Barbara Klinik Hamm GmbH
RECRUITING

Hamm, North Rhine-Westphalia, 59073, Germany
St. Elisabeth-Krankenhaus Köln-Hohenlind
RECRUITING

Cologne, North Rhine-Westphalia, 50935, Germany
Stadtklinik Baden-Baden / Brustzentrum
RECRUITING

Baden-Baden, Baden-Wurttemberg, 76532, Germany
Universitätsklinikum Augsburg A.ö.R.
RECRUITING

Augsburg, Bavaria, 86156, Germany
Universitätsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45130, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89075, Germany
ev. Klinikum Gelsenkirchen - Klinik für Senelogie
RECRUITING

Gelsenkirchen, North Rhine-Westphalia, 45879, Germany

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