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New drug combo could spare chemo for some breast cancer patients

NCT ID NCT05704829

Recruiting now Disease control Sponsor: West German Study Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a personalized treatment plan for people with HER2-positive early breast cancer. It compares a newer drug (trastuzumab-deruxtecan) against standard chemotherapy combinations to see which works better and causes fewer side effects. About 702 participants will receive treatment before surgery, and researchers will track tumor response and long-term outcomes.

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Conditions

The condition(s) this trial relates to.

HER2 positive breast carcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE EARLY BREAST CANCER

Contacts and locations

Locations

  • AGAPLESION Markus Krankenhaus Gynäkologie

    RECRUITING

    Frankfurt am Main, Hesse, 60431, Germany

  • Breast Center of the University of Munich (LMU) Universitätsfrauenklinik

    RECRUITING

    Munich, Bavaria, 80336, Germany

  • Brustzentrum Niederrhein, Johanniter Bethesda Krankenhaus

    RECRUITING

    Mönchengladbach, North Rhine-Westphalia, 41061, Germany

  • Brustzentrum am Krankenhaus Jerusalem

    RECRUITING

    Hamburg, 20357, Germany

  • CaritasKlinikum Saarbrücken St. Theresia

    RECRUITING

    Saarbrücken, Saarland, 66113, Germany

  • Charite Campus Mitte

    ACTIVE_NOT_RECRUITING

    Berlin, 10117, Germany

  • Ev. Waldkrankenhaus Spandau

    RECRUITING

    Berlin, 14589, Germany

  • Frauenklinik / Brustzentrum am Klinikum Obergölzsch Rodewisch

    RECRUITING

    Rodewisch, Saxony, 08228, Germany

  • Frauenklinik St. Louise-St. Vincenz-KH GmbH

    RECRUITING

    Paderborn, North Rhine-Westphalia, 33098, Germany

  • Helios-Klinik Wuppertal

    RECRUITING

    Wuppertal, North Rhine-Westphalia, 42283, Germany

  • Hämotologisch onkologische Praxis Heinrich Bangerter Augsburg GbR

    RECRUITING

    Augsburg, Bavaria, 86150, Germany

  • Kliniken Essen-Mitte, Klinik für Senologie/Interdisziplinäres Brustzentrum

    RECRUITING

    Essen, North Rhine-Westphalia, 45136, Germany

  • Kliniken der Stadt Köln GmbH / Brustzentrum Holweide

    RECRUITING

    Cologne, North Rhine-Westphalia, 51067, Germany

  • Kliniken für Frauenheilkunde / Universitätsklinikum Düsseldorf

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Klinikum Bremerhaven Reinkenheide

    ACTIVE_NOT_RECRUITING

    Bremerhaven, Free Hanseatic City of Bremen, 27574, Germany

  • Klinikum Frankfurt Höchst GmbH

    RECRUITING

    Frankfurt am Main, Hesse, 65929, Germany

  • Klinikum Kassel

    RECRUITING

    Kassel, Hesse, 34125, Germany

  • Klinikum Mittelbaden, Brustzentrum

    RECRUITING

    Baden-Baden, Baden-Wurttemberg, 76532, Germany

  • Klinikum Mutterhaus

    RECRUITING

    Trier, Rhineland-Palatinate, 54290, Germany

  • Luisenkrankenhaus GmbH

    ACTIVE_NOT_RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40235, Germany

  • MKS St. Paulus GmbH

    RECRUITING

    Schwerte, North Rhine-Westphalia, 58239, Germany

  • MVZ Klinik Dr. Hancken GmbH

    RECRUITING

    Stade, Lower Saxony, 21680, Germany

  • MVZ Media Vita am St. Franziskus Hospital

    RECRUITING

    Münster, North Rhine-Westphalia, 48145, Germany

  • Marien-Hospital Witten

    NOT_YET_RECRUITING

    Witten, North Rhine-Westphalia, 58452, Germany

  • Niels-Stensen-Kliniken Franziskus-Hospital

    RECRUITING

    Georgsmarienhütte, Lower Saxony, 49124, Germany

  • Onkodok Gütersloh

    RECRUITING

    Gütersloh, North Rhine-Westphalia, 33332, Germany

  • Onkologische Schwerpunktpraxis Bielefeld

    RECRUITING

    Bielefeld, North Rhine-Westphalia, 33604, Germany

  • Praxis für Interdisziplinäre Onkologie und Hämatologie (PIO)

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79110, Germany

  • Praxisnetzwerk Hämatologie und intern. Onkologie

    RECRUITING

    Troisdorf, North Rhine-Westphalia, 53840, Germany

  • Rotkreuz Klinikum München

    RECRUITING

    Munich, Bavaria, 80634, Germany

  • Sankt-Antonius-Hospital

    RECRUITING

    Eschweiler, North Rhine-Westphalia, 52249, Germany

  • St. Barbara Klinik

    RECRUITING

    Hamm, North Rhine-Westphalia, 59073, Germany

  • St. Elisabeth Krankenhaus GmbH

    RECRUITING

    Cologne, North Rhine-Westphalia, 50935, Germany

  • Studien GbR Braunschweig

    RECRUITING

    Braunschweig, Lower Saxony, 38100, Germany

  • UK Schleswig Holstein

    RECRUITING

    Lübeck, Schleswig-Holsteins, 23538, Germany

  • Uniklinik RWTH Aachen

    RECRUITING

    Aachen, North Rhine-Westphalia, 52074, Germany

  • Universittsklinikum am Klinikum Südstadt

    RECRUITING

    Rostock, Mecklenburg-Vorpommerns, 18059, Germany

  • Universitätsklinikum Augsburg / Klinik für Frauenheilkunde und Geburtshilfe

    RECRUITING

    Augsburg, Bavaria, 86156, Germany

  • Universitätsklinikum Essen, Brustzentrum

    RECRUITING

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitätsklinikum Hamburg-Eppendorf / Klinik und Poliklinik für Gynäkologie

    RECRUITING

    Hamburg, 20246, Germany

  • Universitätsklinikum Leipzig

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitätsklinikum Ulm

    RECRUITING

    Ulm, Baden-Wurttemberg, 89075, Germany

  • Ärztehaus am Bahnhofsplatz

    RECRUITING

    Hildesheim, Lower Saxony, 31134, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.