New hope for CLL patients: a drug that may spare the heart
NCT ID NCT06757647
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether acalabrutinib, a drug similar to ibrutinib, is safer for the heart in people with chronic lymphocytic leukemia (CLL). Many patients on ibrutinib develop heart side effects and have to stop treatment. Researchers will give acalabrutinib to 61 adults with CLL who had heart problems on ibrutinib, and use heart MRIs to check if their heart function improves or stays stable. The goal is to find a treatment that controls the cancer without harming the heart.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acalabrutinib
What this could lead to
If successful, this could show that acalabrutinib is a heart-friendlier option for CLL patients who had heart problems with ibrutinib, allowing them to continue effective cancer treatment.
What could go wrong
This is a small, early-phase study (61 people) with no control group, so results may not apply broadly. Acalabrutinib may still cause heart issues or not control the cancer as well.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact