New pill shows promise against Hard-to-Treat blood cancers
NCT ID NCT04014205
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new drug called orelabrutinib in people with B-cell malignancies, such as certain lymphomas and leukemias. The drug works by blocking a protein that helps cancer cells grow. The trial has two parts: first finding the safest dose, then seeing how well it shrinks tumors. About 81 adults with relapsed or hard-to-treat cancers are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Orelabrutinib (a targeted drug that blocks a protein called BTK to help stop cancer cell growth)
What this could lead to
If successful, this could provide a new treatment option for people with certain B-cell blood cancers, especially those who have not responded to other therapies.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply broadly. The drug may cause side effects or fail to shrink tumors in many patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Anne Arundel Medical Center (AAMC) Oncology and Hematology
Annapolis, Maryland, 21401-3093, United States
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Asclepes Research Centers - Weeki Wachee
Weeki Wachee, Florida, 34607, United States
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Carmel Medical Center
Haifa, Israel
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Cherkassy Regional Oncology Center
Cherkasy, Ukraine
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Clinical Research Alliance
Westbury, New York, 11590, United States
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Coborn Cancer Center
Saint Cloud, Minnesota, 56303, United States
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Cotton O'Neil Cancer Center (Stormont-Vail Cancer Center)
Topeka, Kansas, 66606, United States
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Desert Hematology Oncology Medical Group, Inc.
Rancho Mirage, California, 92270, United States
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Florida Cancer Specialists (FCS) South
Fort Myers, Florida, 33901, United States
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Gabrail Cancer Research Center
Canton, Ohio, 44718, United States
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Goshen Center for Cancer Care
Goshen, Indiana, 46526, United States
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Guthrie Cancer Center
Sayre, Pennsylvania, 18840, United States
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Institute of Blood Pathology and Transfusion Medicine
Lviv, Ukraine
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Khmelnytskyi Regional Hospital
Khmelnytskyi, Ukraine
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Los Angeles Cancer Network - Good Samaritan Hospital Location
Los Angeles, California, 90017, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic - Minnesota
Rochester, Minnesota, 55905-0001, United States
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Mayo Clinic-Mayo Clinic Hospital-Phoenix
Phoenix, Arizona, 85054-4502, United States
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Medical Oncology Associates PS (dba Summit Cancer Centers)
Spokane, Washington, 99201, United States
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National Cancer Institute
Kyiv, Ukraine
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Northwest Neurology - Rolling Meadows Office
Elk Grove Village, Illinois, 60007, United States
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Orchard Healthcare Research Inc.
Skokie, Illinois, 60077, United States
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Pacific Cancer Medical Center
Anaheim, California, 92801-1824, United States
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Prairie Lakes Cancer Center
Watertown, South Dakota, 57201, United States
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Sarah Cannon Research Institute - Tennessee Oncology
Nashville, Tennessee, 37203-1625, United States
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Soroka Medical Center
Beersheba, Israel
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Southeast Nebraska Cancer Center
Lincoln, Nebraska, 68510-2496, United States
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St. Luke's Hospital - Medical and Diagnostic Center
Kropyvnytskyi, Ukraine
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Summit Medical Group
Florham Park, New Jersey, 07932-0001, United States
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Tennessee Cancer Specialists
Knoxville, Tennessee, 37909-1327, United States
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Tennessee Oncology - Chattanooga Oncology & Hematology Associates
Chattanooga, Tennessee, 37404-1130, United States
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The Oncology Institute of Hope & Innovation
Whittier, California, 90603, United States
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Transcarpathian Regional Clinical Hospital named after Andrii Novak
Uzhhorod, Ukraine
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Tulane University School of Medicine - Tulane Cancer Center Comprehensive Clinic TCCCC
New Orleans, Louisiana, 70112, United States
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University of Pittsburgh - Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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Uniwersyteckie Centrum Kliniczne
Gdansk, Poland