New drug aims to shrink cysts in genetic kidney disease

NCT ID NCT06902558

Recruiting now Disease control Sponsor: Calico Life Sciences LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests an investigational drug called ABBV-CLS-628 in adults with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that causes fluid-filled cysts to grow in the kidneys. About 240 participants worldwide will receive either the drug or a placebo by IV every 4 weeks for 92 weeks. The main goal is to see if the drug can slow the increase in total kidney volume and check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-CLS-628
What this could lead to: If successful, this could slow kidney growth and preserve kidney function in people with ADPKD, potentially delaying the need for dialysis or transplant.
What could go wrong: This is an early Phase 2 trial with only 240 participants. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant polycystic kidney disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Contacts and locations

Show contact details

Locations

2CA-Braga, Hospital de Braga
RECRUITING

Braga, Braga District, 4710-243, Portugal
A.O.U. Consorziale Policlinico di Bari
NOT_YET_RECRUITING

Bari, Metropolitan City of Bari, 70124, Italy
AOU di Modena - Ospedale di Modena
NOT_YET_RECRUITING

Modena, Modena, 41124, Italy
Academic Medical Research Institute (AMRI) - Los Angeles
RECRUITING

Los Angeles, California, 90022, United States
Albert Schweitzer Ziekenhuis, locatie Dordwijk
RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
Arlington Nephrology
WITHDRAWN

Arlington, Texas, 76015, United States
Azienda Ospedaliero-Universitaria Policlinico Umberto I
RECRUITING

Rome, Roma, 00161, Italy
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

Contact Email: •••••@•••••
Brookview Hills Research Associates
RECRUITING

Winston-Salem, North Carolina, 27103, United States
CARE Institute - Idaho Falls
RECRUITING

Idaho Falls, Idaho, 83404, United States
CARE-Boise Kidney
RECRUITING

Boise, Idaho, 83706, United States
CHU Brest - Hôpital de la Cavale Blanche
RECRUITING

Brest, Brittany Region, 29200, France
CHU Toulouse - Hôpital Rangueil
RECRUITING

Toulouse, Occitanie, 31400, France
CHU de Liege
RECRUITING

Liège, Liège, 4000, Belgium
Centro Hospitalar Do Funchal
NOT_YET_RECRUITING

Funchal, 9000-168, Portugal
Charite Universitaetsmedizin Berlin - Campus Mitte
RECRUITING

Berlin, State of Berlin, 10117, Germany
Cliniques Universitaires UCL Saint-Luc
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Emory University School Of Medicine - Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States
Erasmus Medisch Centrum
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 AA, Netherlands
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica
NOT_YET_RECRUITING

Rome, Roma, 00168, Italy
Fundacio Puigvert
RECRUITING

Barcelona, Barcelona, 08025, Spain
Hallym University Kangnam Sacred Heart Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 07441, South Korea
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopital Edouard Herriot
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69003, France
Hopital Universitaire Necker Enfants Malades
RECRUITING

Paris, Île-de-France Region, 75015, France
Hopital de la Conception
RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France
Horizon Research Group - Coral Gables
WITHDRAWN

Coral Gables, Florida, 33134, United States
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital Curry Cabral
RECRUITING

Lisbon, Lisbon District, 1069-166, Portugal
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, Madrid, 28040, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Granada, 18014, Spain
Hospital Universitario Virgen del Rocio
NOT_YET_RECRUITING

Seville, Sevilla, 41013, Spain
Humber River Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M3M 0B2, Canada
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Infigo Clinical Research
RECRUITING

Sanford, Florida, 32771, United States

Contact Email: •••••@•••••
Juntendo University Hospital
RECRUITING

Bunkyō-Ku, Tokyo, 113-8431, Japan
Keimyung University Dongsan Hospital
RECRUITING

Daegu, Gyeongsangbuk-do, 42601, South Korea
Knoxville Kidney Center
RECRUITING

Knoxville, Tennessee, 37923, United States
LUMC
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Lakeridge Health Corporation-Oshawa
NOT_YET_RECRUITING

Oshawa, Ontario, L1H 2B9, Canada
Mayo Clinic Hospital - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medical University of South Carolina
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany
National Hospital Org Chiba Medical Center Chibahigashi National Hospital
RECRUITING

Chiba, Chiba, 260-8712, Japan
National Hospital Organization Kyoto Medical Center
RECRUITING

Kyoto, Kyoto, 612-8555, Japan
National Institute of Clinical Research - Pomona
RECRUITING

Pomona, California, 91768, United States
Nature Coast Clinical Research - Inverness
RECRUITING

Inverness, Florida, 34452-4717, United States
Nephrology Associates - Chattanooga - East Third Street
RECRUITING

Chattanooga, Tennessee, 37404, United States
Northeast Clinical Research Center
RECRUITING

Bethlehem, Pennsylvania, 18017, United States
Northwestern University Feinberg School of Medicine
RECRUITING

Chicago, Illinois, 60611-2927, United States
Panax Clinical Research
RECRUITING

Miami, Florida, 33014, United States
Pusan National University Hospital
RECRUITING

Busan, Busan Gwang Yeogsi, 49241, South Korea
Renal Disease Research Institute
RECRUITING

Fort Worth, Texas, 76104, United States
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia
SMG-SNU Boramae Medical Center
ACTIVE_NOT_RECRUITING

Seoul, Seoul Teugbyeolsi, 07061, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
South Florida Research Institute
RECRUITING

Fort Lauderdale, Florida, 33313, United States
St. Clair Nephrology
RECRUITING

Shelby, Michigan, 48315, United States
St. Michael's Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Swedish Medical Center - Seattle
RECRUITING

Seattle, Washington, 98104, United States
TUM Klinikum rechts der Isar
RECRUITING

Munich, Bavaria, 81675, Germany
The Vanderbilt University Medical Center (VUMC)
NOT_YET_RECRUITING

Nashville, Tennessee, 37212, United States
Toronto General Hospital-University Health Network
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111-1552, United States
UC Irvine Medical Center
RECRUITING

Orange, California, 92868-3201, United States
UZ Leuven
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
Unidade Local de Saude de Almada-Seixal, EPE
RECRUITING

Almada, Setúbal District, 2805-267, Portugal
Unidade Local de Saude de Lisboa Ocidental, EPE
RECRUITING

Lisbon, Lisbon District, 2799-523, Portugal
Unidade Local de Saude do Algarve, EPE
RECRUITING

Faro, Faro District, 8000-386, Portugal
Universitaetsklinikum Heidelberg
NOT_YET_RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Koeln
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Universitair Medisch Centrum Groningen
WITHDRAWN

Groningen, Provincie Groningen, 9713 GR, Netherlands
University Of California, San Francisco
RECRUITING

San Francisco, California, 94143-2202, United States
University Of Michigan
RECRUITING

Ann Arbor, Michigan, 48109-5000, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California Los Angeles Medical Center
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Miami Don Suffer Clinical Research Building
RECRUITING

Miami, Florida, 33136, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599-0001, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Valiance Clinical Research - Huntington Park
RECRUITING

Huntington Park, California, 90255, United States
Washington University School of Medicine - St Louis
RECRUITING

St Louis, Missouri, 63110, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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