Withdrawn trial sought to protect gut cells in GVHD patients
NCT ID NCT06598332
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial aimed to test whether adding the drug 5-azacytidine (AZA) to standard steroid treatment could protect gut stem cells in patients with gastrointestinal graft-versus-host disease (GVHD), a serious complication after a donor stem cell transplant. The study planned to enroll people aged 12 and older experiencing their first episode of gut GVHD. However, the trial was withdrawn before any participants were enrolled, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
5-azacytidine
What this could lead to
If it works, this could point toward a better first-line treatment for GI GVHD that protects gut stem cells and reduces long-term damage.
What could go wrong
This trial was withdrawn before enrolling any participants, so no data exists. The approach is very early-stage, and 5-azacytidine is not FDA-approved for GVHD, so its safety and effectiveness are unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States