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Withdrawn trial sought to protect gut cells in GVHD patients

NCT ID NCT06598332

Terminated Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial aimed to test whether adding the drug 5-azacytidine (AZA) to standard steroid treatment could protect gut stem cells in patients with gastrointestinal graft-versus-host disease (GVHD), a serious complication after a donor stem cell transplant. The study planned to enroll people aged 12 and older experiencing their first episode of gut GVHD. However, the trial was withdrawn before any participants were enrolled, so no results are available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
5-azacytidine
What this could lead to
If it works, this could point toward a better first-line treatment for GI GVHD that protects gut stem cells and reduces long-term damage.
What could go wrong
This trial was withdrawn before enrolling any participants, so no data exists. The approach is very early-stage, and 5-azacytidine is not FDA-approved for GVHD, so its safety and effectiveness are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute graft versus host disease graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT VERSUS HOST DISEASE (GVHD)

Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

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