Wake Forest University

This trial tests whether a 48-month program of dietary weight loss, exercise, and weight maintenance can prevent knee osteoarthritis in women aged 50 and older who have obesity and no or infrequent knee pain. Participants are randomly assigned to the diet-and-exercise program or …

This early study tests whether injecting a patient's own muscle fibers into the bladder neck or urethra is safe for treating urinary incontinence. Ten adult women with incontinence due to a weak outlet will be monitored for side effects and changes in leakage over 12 months.

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study looks at how cooling the thigh muscle changes the way nerves control it. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to see if this method works well, so they can plan larger studies later. No treatment is…