Nuvation Bio Inc.

This study tests an experimental drug called safusidenib in people with a slow-growing brain tumor (IDH1-mutant glioma) whose tumor got worse while on the standard drug vorasidenib. Up to 40 participants take safusidenib pills twice daily to see if the tumor shrinks or stops grow…

This study tests whether the experimental drug safusidenib can slow or stop the growth of a type of slow-growing brain tumor called grade 2 glioma that has a specific genetic change (IDH1 mutation). Participants have had surgery but no other treatments like chemotherapy or radiat…

This study in healthy adults tests whether famotidine, a common heartburn medication, changes how the body absorbs and processes taletrectinib, an experimental cancer drug. Participants receive taletrectinib alone or with different doses and timings of famotidine to compare drug …