Institute Of Cancer Research, United Kingdom

This phase 3 trial is for post-menopausal women with a common type of breast cancer that has a high chance of coming back. Participants receive either standard hormone therapy alone or with the addition of abemaciclib, a targeted drug that blocks cancer cell growth. The goal is t…

This study tests a new drug (ceralasertib) alone or with either a targeted therapy (olaparib) or an immunotherapy (durvalumab) in 174 people with advanced gynaecological cancers that have returned after treatment. The goal is to see if these combinations work better in cancers wi…

This study looks at whether men with advanced prostate cancer that no longer responds to hormone therapy have certain gene changes that make them more likely to benefit from a chemotherapy drug called carboplatin. Researchers will first screen participants for these gene changes,…

This early-phase study tests whether combining two drugs—tepotinib and pembrolizumab—can help treat advanced non-small cell lung cancer (NSCLC) that doesn't respond to standard immunotherapy. The trial includes 19 adults with NSCLC, some with a specific MET gene mutation. The goa…

This study looks at men aged 40-69 who have certain gene mutations (BRCA1, BRCA2, or mismatch repair) that raise their risk for prostate cancer. Researchers give annual PSA tests to see how often cancer is found compared to men without these mutations. The goal is to learn more a…

This study looks at whether a man's genetic profile can help doctors decide who should be screened for prostate cancer. About 300 men aged 55-69 will have their genes checked and those with higher genetic risk will be offered a prostate biopsy. The goal is to see if this approach…

This large study looks at the DNA of nearly 24,000 men with prostate cancer to find inherited genes that increase risk. It focuses on younger men and those with a family history, where genetics likely play a bigger role. The goal is to understand why some families have higher rat…

This study takes blood samples from 25 cancer patients before and during radiotherapy to measure gene activity changes caused by radiation. The goal is to find a set of genes that can show how each person's body responds to treatment. This is an observational study that does not …