Institut De Recherches Internationales Servier

This study is testing two different drugs, ivosidenib and azacitidine, for adults with a type of blood cancer called myelodysplastic syndromes (MDS) who have a specific genetic change (IDH1 mutation) and have not yet received standard treatment. Participants will be randomly assi…

This is the first study in humans of an experimental drug called S230815 for children with a severe form of epilepsy caused by a specific genetic change (KCNT1). Researchers will give the drug via spinal injection to 20 children aged 2-12 to check if it is safe and how the body p…

This study is testing a new oral drug, S241656, alone and in combination with other cancer therapies. It aims to find a safe and effective dose for adults with advanced cancers, including lung, pancreatic, and colorectal cancers, that have specific genetic mutations like KRAS or …

This study is testing whether adding two newer drugs (ivosidenib and durvalumab) to standard chemotherapy works better for people with advanced bile duct cancer that has a specific genetic change called IDH1 mutation. The trial will first check if the combination is safe, then se…