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New hope for kids with rare epilepsy: first human trial launches

NCT ID NCT07227857

Recruiting now Disease control Sponsor: Institut de Recherches Internationales Servier Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tests a new medicine (S230815) for children aged 2-12 with a rare, severe epilepsy caused by changes in the KCNT1 gene. The goal is to see if the drug is safe and can help control seizures. About 20 children will take part, receiving the drug through a spinal injection over several weeks.

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Conditions

The condition(s) this trial relates to.

developmental and epileptic encephalopathy developmental and epileptic encephalopathy, 14

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPTIC ENCEPHALOPATHY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Azienda Ospedaliera Universitaria Meyer IRCCS

    NOT_YET_RECRUITING

    Florence, 50139, Italy

  • Boston Children's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Children's Hospital of Orange County

    NOT_YET_RECRUITING

    Orange, California, 92868, United States

  • Hopital Necker Enfants Malades

    RECRUITING

    Paris, 75015, France

  • Hospital Ruber Internacional

    RECRUITING

    Madrid, 28035, Spain

  • Hospital Sant Joan De Deu Barcelona

    RECRUITING

    Esplugues de Llobregat, 08950, Spain

  • Institut Des Neurosciences De La Timone

    RECRUITING

    Marseille, 13005, France

  • Nationwide Children's Hospital

    NOT_YET_RECRUITING

    Columbus, Ohio, 43205, United States

  • Osaka City General Hospital

    RECRUITING

    Osaka, Japan

  • Ospedale Pediatrico Bambino Gesu

    NOT_YET_RECRUITING

    Roma, 00165, Italy

  • Robert Debre University Hospital

    RECRUITING

    Paris, 75019, France

  • Shinshu University Hospital

    RECRUITING

    Nagano, Japan

  • Shizuoka Institute of Epilepsy and Neurological Disorders

    RECRUITING

    Shizuoka, Japan

  • The Children's Hospital of Philadelphia

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester Medical Center

    NOT_YET_RECRUITING

    Rochester, New York, 14642, United States

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