China National Center For Cardiovascular Diseases

This study tests a digital health tool called "Smart family doctor" that uses artificial intelligence to help people who have had heart surgery or stents manage their blood pressure, diabetes, and cholesterol. About 951 adults aged 18-80 will be randomly assigned to use the tool …

This study tests a new way to close a common heart hole (atrial septal defect) using only ultrasound, without X-rays or cuts. The procedure is done inside a specially equipped mobile surgical unit, bringing care to remote areas. About 300 people aged 8 and older will take part to…

This study compares two types of drug-coated balloons used to open blocked heart arteries in people with acute coronary syndrome (a serious heart condition). About 60 adults will receive either a sirolimus-coated or paclitaxel-coated balloon. The main goal is to see which balloon…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study looks at whether people with a CH-VAD heart pump can safely stop taking aspirin while continuing other blood thinners. About 370 adults who have had the pump implanted for advanced heart failure will be randomly assigned to receive either a placebo or aspirin. The goal…

This study tests whether a smart lifestyle program that combines diet advice with exercise coaching can improve health in 435 adults aged 20-60 who are overweight or obese and have metabolic syndrome. Participants will be split into two groups: one gets simple diet advice, the ot…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can prevent blood clots on the new heart valve in people who have had a minimally invasive aortic valve replacement (TAVR). About 116 patients aged 60-85 will receive either colchicine plus standard car…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP) can prevent acute kidney injury in 694 high-risk adults undergoing heart surgery with a heart-lung machine. Participants receive the drug or a placebo continuously for about 48 hours during…

This study tests whether nicorandil, a drug that opens potassium channels, can improve the function of tiny heart blood vessels after a heart attack. About 170 adults with ST-elevation heart attacks who are getting angioplasty will receive nicorandil or a placebo. The goal is to …

This study tests whether a robotic system can safely assist doctors in opening blocked heart arteries. About 170 adults with coronary artery disease will be randomly assigned to receive the standard procedure or one assisted by the robot. The goal is to see if the robot can reduc…

This study tests a tool called SCOUT that helps doctors check AI-generated diagnoses for coronary heart disease. Seven cardiologists will review cases either with or without SCOUT's help to see if it saves time while keeping accuracy high. The goal is to make AI safer and more us…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This study tests whether using only ultrasound (echo) to guide a minimally invasive heart valve replacement is as effective as the standard method that also uses X-rays. The goal is to reduce the risk of kidney injury from contrast dye and lower radiation exposure. About 212 adul…

This study tests a new way to treat atrial fibrillation (AFib), a condition that causes an irregular heartbeat. The procedure uses a special energy called pulsed field ablation, which may be safer for nearby organs than current heat or cold methods. Doctors will also use a 3D ult…

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study tests whether personalized video feedback created by artificial intelligence can help heart surgeons get better at coronary artery bypass surgery. About 100 surgeons will submit a video of their surgery, get AI-generated feedback on areas to improve, then practice for …

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study involves 800 elderly patients (70 and older) with heart artery disease. Researchers will use CT scans, frailty assessments, and blood tests to create a model that predicts the risk of major heart events over two years. The goal is to improve treatment decisions without…

This study compares two imaging methods—CT-FFR and QFR—to help doctors decide the best treatment for people with narrowed heart arteries. About 1,400 adults with moderate blockages will be randomly assigned to one of the two methods. The goal is to see which approach reduces the …

This study will develop a computer model that uses machine learning to predict a patient's risk of developing acute kidney disease after heart surgery. Researchers will collect data from 820 adults undergoing certain heart procedures to build and test the model. The goal is to cr…

This study will follow 6,000 adults in China who have both coronary heart disease and a leaky heart valve (ischemic mitral regurgitation). Researchers will collect medical data and track participants for 2 years to see how the condition progresses and what treatments are used. Th…

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study looks at 421 people who are getting a heart device (ICD) to see if muscle health can help predict sudden cardiac death. Researchers will use AI to combine muscle scans, blood tests, and other data to build a risk prediction tool. No new treatments are tested—the goal i…