Canadian Cancer Trials Group

This study tested giving chemotherapy before a less invasive surgery for early rectal cancer. The goal was to see if this approach could allow patients to keep their rectum instead of needing major surgery. 58 people took part, and the treatment was considered successful if at le…

This study tested a new drug called RP-6306 in 28 people with advanced cancer that could not be cured. The goal was to see if the drug is safe and if it works better when added to standard treatment. Researchers also checked if certain biomarkers helped predict a stronger respons…

This study tested two different dosing schedules of the drug palbociclib combined with hormone therapy in 180 women with advanced, hormone-receptor-positive breast cancer. The goal was to see if a lower daily dose (100 mg) works as well as the standard higher dose (125 mg) but wi…

This study looked at whether a structured physical activity program, along with health education materials, could help prevent colon cancer from returning in people who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. About 889 participants were rand…

This study compared two types of radiation therapy for men with intermediate-risk prostate cancer: standard image-guided external beam radiation (IGRT) versus IGRT plus a high-dose-rate brachytherapy boost. The goal was to see which treatment works better and what side effects oc…

This early-phase study tested a new combination of drugs (romidepsin plus standard chemotherapy) in 21 patients with two types of lymphoma. The main goal was to find the safest dose and understand side effects. Researchers hope this approach could lead to better outcomes, but mor…

This study tested whether a single immunization with IMM-101 could help prevent severe respiratory infections, including COVID-19, in cancer patients who are at higher risk. About 195 participants receiving active cancer treatment were randomly assigned to get the shot or just be…