Bruyère Health Research Institute.

This phase 3 trial tests whether daily low-dose psilocybin (2-3 mg) can reduce psychological distress in 120 adults with advanced illness who have 2-12 months to live. Participants take the drug four days a week for two weeks, without therapy. The study compares psilocybin to a p…

This trial tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely and feasibly treat prolonged grief disorder. Fifteen bereaved adults with high grief scores will receive eight sessions of rTMS daily for five…

This study is testing whether a Memory Support System (MSS) is practical and helpful for people with mild cognitive impairment (MCI) and their care partners. About 40 participants will try the MSS and report on their daily function, memory confidence, mood, and quality of life. T…

This study tests a program called FRAME that helps heart failure patients discuss stress, anxiety, and depression with their doctors and loved ones. About 7,300 patients in Ontario, Canada will take surveys before and after using the tool. The goal is to see if the program makes …

This study tests a toolkit called STEP that helps long-term care residents, their families, and nurses make better decisions about whether to go to the hospital during a health crisis. About 200 residents and their care partners will use the toolkit and complete surveys to measur…