Biosplice Therapeutics, Inc.

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate to severe knee osteoarthritis. The goal was to see if it could reduce pain and improve function over 56 weeks compared to a placebo. Participants were between 40 and 80 years old …

This study tested a single injection of lorecivivint in the knee joint of 496 adults with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo over 28 weeks. Participants reported their pain levels weekly using…

This study tested an experimental drug called SM04690, given as two injections into the knee about six months apart, in 101 people with moderate to severe knee osteoarthritis. The main goal was to check safety and measure changes in bone density in the treated knee compared to a …