Abramson Cancer Center At Penn Medicine

This pilot study explores whether a special PET/CT scan that tracks CD8 immune cells can help select the best tumors for harvesting immune cells (TILs) to treat stage IV melanoma. Participants receive the TIL therapy lifileucel (AMTAGVI) after a chemotherapy regimen. The goal is …

This early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …

This study tests whether giving focused radiation or surgery to all visible tumors (both the original kidney tumor and its metastases) can allow people with advanced kidney cancer to stop all cancer treatments for at least a year. Participants must have stable or partially improv…

This pilot study tests whether a dye called TumorGlow (indocyanine green) can help surgeons see and remove sarcoma tumors that have spread to the lungs in children aged 12 to 17. The dye is given intravenously up to five days before surgery, and during the operation, a special ca…

This study tests whether injecting a virus called RP2 directly into stomach and esophageal tumors, combined with standard FLOT chemotherapy, is safe and works better than chemotherapy alone before surgery. About 34 people with stage II or higher non-metastatic gastroesophageal ca…

This study will check how well a new blood test, called SpotitEarly, can detect breast cancer in women. About 500 women will take part, including those at higher risk due to age, genetics, or family history. The goal is to see if the test is accurate and works well for different …