UVEAL MELANOMA

This study tests a drug called darovasertib in 160 people with a rare eye cancer (uveal melanoma). The goal is to shrink tumors so that some patients can avoid losing their eye and instead receive radiation. The drug is taken by mouth and aims to control the cancer, not cure it, …

This early-stage study tests a new drug called IOA-244 in about 210 adults with advanced or metastatic cancers like lung cancer, melanoma, and lymphoma. The main goal is to see if the drug is safe and tolerable, both alone and combined with other treatments. Researchers also chec…

This study tests a new way to treat large eye cancers (uveal melanoma). Doctors give a chemotherapy drug directly into the blood vessels feeding the tumor to shrink it, then follow up with radiation. The goal is to make the tumor small enough for safe radiation. Ten adults with t…

This study tests a new drug called roginolisib in adults with advanced uveal melanoma, a rare eye cancer that has spread. About 85 participants will receive either roginolisib or standard treatment to see if the drug helps them live longer and improves their quality of life. The …

This early-phase study tests a radioactive drug called 225Ac-MTI-201 in 16 people with metastatic uveal melanoma, a rare eye cancer that has spread. The main goal is to find the highest safe dose and understand side effects. Participants must have already tried at least one other…

This study follows 500 adults with uveal melanoma (a rare eye cancer) to measure how diagnosis and treatment affect their quality of life, mental health, and decision-making. Participants complete surveys before treatment and for five years after. The goal is to better understand…

This study screens up to 1,150 adults with advanced solid tumors like head and neck, cervical, or lung cancer. Researchers collect blood or tissue samples to check for specific genetic markers and tumor proteins. The goal is to identify patients who might be eligible for future t…

This study looks at whether eating a high-fiber diet can change the gut bacteria of people with advanced melanoma who are receiving standard immunotherapy. About 50 participants will be randomly assigned to either a high-fiber or a healthy control diet for a set period. The main …

This study tests whether a video-based educational program can help people who have had uveal melanoma (a rare eye cancer) better understand their disease and feel more in control. About 108 adults who completed treatment are randomly assigned to watch the video or receive usual …