UNRESECTABLE MELANOMA
Clinical trials for UNRESECTABLE MELANOMA explained in plain language.
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Milder chemo before TIL therapy shows promise for tough-to-treat melanoma
Disease control CompletedThis phase 2 trial tested whether a reduced dose of chemotherapy drugs (fludarabine and cyclophosphamide) given before infusing a patient's own tumor-fighting immune cells (lifileucel) could work for advanced melanoma that has spread or can't be removed. Eleven adults with stage …
Matched conditions: UNRESECTABLE MELANOMA
Phase: PHASE2 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Supercharged immune cells take on tough melanoma
Disease control CompletedThis early-phase trial tested a new personalized therapy called TBio-4101 for people with advanced melanoma that had stopped responding to standard treatments. The therapy uses a patient's own tumor-fighting immune cells, which are collected, multiplied in the lab, and then infus…
Matched conditions: UNRESECTABLE MELANOMA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New drug cocktail targets Hard-to-Treat melanoma
Disease control CompletedThis early-phase trial tested a combination of two oral drugs, trametinib and ceritinib, in 27 people with advanced melanoma that had stopped responding to prior treatments. The main goals were to find a safe dose and see if the combination could shrink tumors. The study is compl…
Matched conditions: UNRESECTABLE MELANOMA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New vaccine combo shows promise for hard-to-treat melanoma
Disease control CompletedThis phase 2 trial tested a combination of an experimental cancer vaccine (BNT111) and an immunotherapy drug (cemiplimab) in 184 adults with advanced melanoma that no longer responded to standard immunotherapy. Participants were randomly assigned to receive the combination or eit…
Matched conditions: UNRESECTABLE MELANOMA
Phase: PHASE2 • Sponsor: BioNTech SE • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Two-Drug combo shows promise against tough skin cancer
Disease control CompletedThis phase II trial tested whether adding bevacizumab to the immunotherapy drug ipilimumab helps people with advanced melanoma that cannot be removed by surgery. The study enrolled 169 participants and measured overall survival and tumor progression. The goal was to see if the co…
Matched conditions: UNRESECTABLE MELANOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC