STAGE II LUNG CANCER AJCC V8

This study tests whether giving the immunotherapy drug durvalumab after surgery can prevent early-stage non-small cell lung cancer from coming back. About 306 people who have had their lung cancer completely removed will either receive durvalumab or be watched closely (standard c…

This study is for people with stage II to IIIB non-small cell lung cancer that has been surgically removed. It tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help keep the cancer from coming back and extend survival. About 1,210 participant…

This study tests whether doing special breathing exercises before lung cancer surgery can help prevent serious lung problems like pneumonia after the operation. About 220 people with stage I-IIIB lung cancer will either do these exercises or receive usual care. The goal is to see…

This study tests whether artificial intelligence (AI) can help doctors choose the right radiation dose for people with lung cancer or lung tumors that have spread from other cancers. About 70 participants will receive a precise type of radiation called SBRT, with the dose guided …

This study compares two standard approaches for people with stage II-IIIB non-small cell lung cancer that can be removed with surgery. One group gets chemotherapy and immunotherapy both before and after surgery, while the other gets the same treatments only after surgery. The goa…

This study tests whether giving a combination of two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more tumor cells in people with stage IB to IIIB non-small cell lung cancer. About 60 adults will receive the drug combination before their tumor is removed…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage and cancer development. The goal is to see if this approach can stop lu…

This study tests whether a home-based breathing exercise program can help people who have finished treatment for early-stage lung cancer (stages I-III) feel less breathless, less tired, and more active. About 100 survivors will do breathing exercises at home for several weeks. Re…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study looks at whether giving early-stage lung cancer patients detailed information about quality of life outcomes helps them feel more satisfied with their choice between surgery and radiation therapy. About 150 adults with stage I or II lung cancer who are eligible for bot…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study tests a conversation aid that helps lung cancer patients and their doctors share decision-making about treatment. About 100 patients with non-small cell lung cancer will use the tool during appointments, and researchers will measure how involved patients feel and how s…

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…