STAGE I PROSTATE CANCER AJCC V8

This study tests whether adding the drug apalutamide to standard hormone therapy and radiation helps men with prostate cancer that has spread to lymph nodes after surgery. About 586 participants will receive either the usual treatment or the usual treatment plus apalutamide. The …

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many doctors avoid TRT in these patients due to fear it might make the cancer grow. The trial will tr…

This study tests a procedure called TULSA that uses MRI-guided sound waves to destroy prostate tumors without cutting into the body. It is for men aged 45-80 with low to intermediate grade prostate cancer. The goal is to see if this approach can control the cancer while helping m…

This study tests a special tissue wrap placed on nerves during prostate removal surgery to see if it helps men recover erectile and bladder control faster. About 25 men with localized prostate cancer will take part. The wrap acts as a protective barrier, and researchers will chec…

This study tests whether high-dose vitamin D can prevent bone loss in men aged 50+ with prostate cancer who are receiving hormone therapy (ADT). ADT can weaken bones, raising the risk of fractures. Researchers will give 240 participants either high-dose vitamin D or a placebo for…

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive the scan beforehand. The goal is to see if the sc…

This study tests whether two radiation treatments with advanced targeting cause fewer side effects than the usual five treatments for men with localized prostate cancer. About 144 participants will receive either the shorter or standard approach, and researchers will track qualit…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time motion tracking during treatment, doctors hope to target the tumor more precisely and reduce common side effects like urinary and bowel problems. About 80 men with early-sta…

This study tests a smarter way to deliver radiation for prostate cancer that hasn't spread. Instead of using a fixed plan, doctors adjust the radiation each day based on real-time images of the prostate and bladder. The goal is to see if this approach lowers urinary side effects …