SMOLDERING MULTIPLE MYELOMA

This early-phase study tests a cancer vaccine (PVX-410) together with two other drugs (citarinostat and lenalidomide) in 19 people with smoldering multiple myeloma, a pre-cancer condition. The main goal is to see if the combination is safe and tolerable, and to check if it boosts…

This study tests whether the drug daratumumab can delay or prevent smoldering multiple myeloma from turning into active multiple myeloma. About 390 people with high-risk smoldering myeloma received either daratumumab injections or were simply monitored. The goal is to see if the …

This study looked at whether taking lenalidomide (a drug that helps the immune system fight cancer) after a stem cell transplant can keep multiple myeloma from coming back longer than taking a placebo. About 460 people with active multiple myeloma took part. The goal was to see h…

This study compares the drug lenalidomide to simply watching and waiting in 226 people with high-risk smoldering multiple myeloma, a condition that often turns into active cancer. The goal is to see if lenalidomide can delay progression and improve survival without causing seriou…

This study tests a drug called daratumumab in people with two early blood conditions: high-risk MGUS and low-risk smoldering multiple myeloma. The goal is to see if the drug can deeply reduce or eliminate abnormal cells, potentially delaying or preventing progression to active my…

This study tests whether a CAR-T cell therapy called cilta-cel is safe and effective for people with high-risk smoldering myeloma, an early form of multiple myeloma. About 20 participants will receive the treatment along with chemotherapy to prepare their immune system. The goal …

This study tests whether a plant-based diet is practical for overweight people with early blood conditions called MGUS or smoldering multiple myeloma. Researchers will see if participants can stick to the diet and lose weight, and whether it helps prevent progression to multiple …

This study tests whether metformin, a common diabetes medicine, can stop early blood conditions (MGUS and smoldering multiple myeloma) from turning into multiple myeloma. About 60 participants will receive either metformin or a placebo pill. Researchers will track changes in bloo…

This study collects bone marrow and blood samples, along with medical history, from people with multiple myeloma, Waldenstrom macroglobulinemia, and related disorders. The samples are stored in a tissue bank for future research to understand what causes these cancers and how to i…