SMOLDERING MULTIPLE MYELOMA

This phase 3 trial studies whether taking lenalidomide (Revlimid) after an autologous stem cell transplant can delay the return of multiple myeloma compared to a placebo. About 460 patients with active myeloma who had a stem cell transplant are involved. The main goal is to see h…

This study compares the drug lenalidomide to simply watching and waiting in people with high-risk smoldering multiple myeloma, a condition that may turn into active cancer. The goal is to see if lenalidomide can delay progression and improve outcomes. About 226 participants were …

This phase 2 trial is testing the drug daratumumab in 42 people with high-risk MGUS or low-risk smoldering multiple myeloma—early, pre-cancerous conditions that can lead to multiple myeloma. The goal is to see if daratumumab can produce a deep response (very good partial response…

This early-phase trial tests a cancer vaccine (PVX-410) combined with two drugs (citarinostat and lenalidomide) in 19 people with smoldering multiple myeloma, a pre-cancer condition. The goal is to see if the combination is safe and can trigger an immune response against myeloma …

This study tests a CAR-T cell therapy called cilta-cel in 20 people with high-risk smoldering myeloma, an early form of multiple myeloma. The treatment uses a patient's own immune cells, modified to attack cancer cells, along with chemotherapy. The goal is to see if it is safe an…

This study is testing a blood screening program to find multiple myeloma and its early stages (MGUS and smoldering myeloma) in Black adults aged 50 and older. Participants get a simple blood test and fill out questionnaires about their experience and knowledge of the disease. Tho…

This phase 2 trial is testing whether metformin, a widely used diabetes medication, can prevent progression to multiple myeloma in 60 people with early blood disorders called MGUS and smoldering multiple myeloma. Participants receive either extended-release metformin or a placebo…

This study tests whether a plant-based diet is practical for overweight people with MGUS or smoldering multiple myeloma, conditions that can lead to multiple myeloma. For 12 weeks, 23 participants receive two pre-made plant-based meals daily. Researchers track weight loss and die…

This study collects bone marrow and blood samples, along with medical history, from people with multiple myeloma, Waldenstrom macroglobulinemia, and related disorders. The samples are stored in a tissue bank for future research to understand what causes these cancers, how they pr…