SMOLDERING MULTIPLE MYELOMA

This study tested whether taking a daily pill called lenalidomide after a stem cell transplant could help patients with multiple myeloma live longer without their cancer getting worse. About 460 patients who had their own stem cells transplanted were randomly assigned to receive …

This study is for people with high-risk smoldering multiple myeloma, a silent, early-stage blood cancer that has not yet caused symptoms. It compares starting treatment early with a drug called lenalidomide against the standard approach of watchful waiting. The main goal is to se…

This study is testing whether a CAR-T cell therapy called cilta-cel can safely and effectively treat people with high-risk smoldering myeloma—an early, pre-cancerous stage of multiple myeloma. Researchers will collect and modify participants' own immune cells to target and destro…

This early-stage study is testing the safety of a new cancer vaccine (PVX-410) combined with other drugs for people with smoldering multiple myeloma, an early form of blood cancer. The goal is to see if these combinations can safely boost the immune system to fight the cancer cel…

This study is testing whether the drug daratumumab can prevent or delay the progression to active multiple myeloma in people with high-risk early-stage conditions (MGUS or smoldering myeloma). The trial involves 42 participants who have these conditions but do not yet have sympto…

This small pilot study is testing whether a 12-week whole food, plant-based diet is practical and helpful for overweight people with early blood cell conditions (MGUS or smoldering myeloma) that can sometimes turn into cancer. Researchers want to see if participants can stick to …

This study is testing whether giving the drug daratumumab early, as an injection under the skin, can delay or prevent high-risk smoldering multiple myeloma from turning into active multiple myeloma that requires treatment. It will compare the drug against active monitoring (watch…

This study is testing whether metformin, a common diabetes medication, can prevent people with early blood cell conditions (MGUS and smoldering myeloma) from developing full multiple myeloma, a type of blood cancer. About 60 participants will take either metformin or a placebo pi…

This study collects blood and bone marrow samples from people with multiple myeloma and related blood cancers to build a research database. Participants also provide medical history through a questionnaire. The goal is to help scientists understand these diseases better and devel…