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This early-stage trial is testing a new type of immune cell therapy called CAR-T cells that target a protein called B7-H3 on triple-negative breast cancer cells. The cells also have a safety switch to stop them if needed. Up to 42 adults whose cancer has returned or not responded…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This early-phase study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side eff…

This study is for people with colorectal cancer that came back within a year after finishing initial chemotherapy. It tests whether adding an immunotherapy drug called serplulimab to standard second-line chemo and targeted therapy can help control the cancer longer. About 40 part…

This phase 2 study is testing whether combining two drugs—epcoritamab and loncastuximab tesirine—can safely shrink or eliminate lymphoma in people whose large B-cell lymphoma has come back or not responded to treatment. About 26 adults will receive the drugs over several cycles. …

This study tests a new treatment called iC9-CAR.CSPG4 T cells for people with head and neck cancer that has come back after standard treatments. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The main goals are to fin…

This study tests a new type of immunotherapy called CAR-T cells, which are specially engineered to recognize and attack CD30, a protein found on Hodgkin lymphoma cells. The trial enrolls up to 31 adults whose cancer has returned or not responded to standard treatments. Participan…

This study is developing a machine learning model to predict the risk of relapse within one year for people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a fungus. Researchers will collect data from 300 patients across mul…

This study looks at how different face shapes (horizontal vs. vertical growers) affect tooth movement after braces are removed, during the retention phase when retainers are worn. Researchers will track 44 people over 12 months using 3D scans to see if teeth shift differently bas…