REFRACTORY MELANOMA
Clinical trials for REFRACTORY MELANOMA explained in plain language.
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Last hope? drug combo targets melanoma that beat immunotherapy
Disease control OngoingThis early-phase study tests whether adding a drug called rigosertib to the immunotherapy pembrolizumab can help people with advanced melanoma that no longer responds to standard immunotherapy. The trial enrolled only 7 adults with melanoma that had spread or couldn't be removed.…
Matched conditions: REFRACTORY MELANOMA
Phase: PHASE2 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Disease control
Last updated May 17, 2026 08:03 UTC
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Experimental combo aims to starve and attack tumors
Disease control OngoingThis early-phase trial tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and ziv-aflibercept (which cuts off blood supply to tumors)—in people with advanced solid tumors that have spread. The main goal is to find the safes…
Matched conditions: REFRACTORY MELANOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 08:03 UTC
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New hope for kids with rare cancers: targeted drug takes aim at HRAS gene
Disease control OngoingThis study tests a drug called tipifarnib in children and young adults (ages 1 to 21) whose cancer has returned or spread and has a specific change in the HRAS gene. The goal is to see if the drug can shrink tumors or stop them from growing. About 5 participants received the drug…
Matched conditions: REFRACTORY MELANOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 08:00 UTC
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New drug cocktail shows promise for deadly brain tumors in melanoma patients
Disease control OngoingThis study tests whether combining two or three drugs can shrink or control melanoma that has spread to the brain. The drugs work by blocking tumor growth and helping the immune system attack cancer cells. The trial involves 29 adults with untreated brain metastases and aims to s…
Matched conditions: REFRACTORY MELANOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 07:57 UTC
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Last-Resort drug made available for stubborn melanoma patients
Disease control NO_LONGER_AVAILABLEThis program offers compassionate access to vidutolimod for people with refractory melanoma, a type of skin cancer that has not responded to standard treatments. The goal is to provide a potential treatment option when no others are available. The study is no longer enrolling par…
Matched conditions: REFRACTORY MELANOMA
Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated May 13, 2026 15:58 UTC