RECURRENT MALIGNANT GLIOMA

This early-phase trial tests a new type of immune cell therapy (CAR T cells) designed to target and kill glioblastoma, an aggressive brain cancer that has returned or worsened. The therapy uses a special targeting domain (chlorotoxin) to seek out cancer cells. The study involves …

This study tests a drug called ivosidenib in children and young adults (ages 1-21) whose cancers have a specific IDH1 gene change and have either returned or not responded to standard treatments. The goal is to see if the drug can shrink tumors. Only 3 participants were enrolled,…

This study tests a drug called larotrectinib in children and young adults (ages 1 to 21) whose advanced or recurrent solid tumors, lymphoma, or histiocytic disorders have a specific genetic change called an NTRK fusion. The drug works by blocking enzymes that help cancer cells gr…

This study tests a drug called tipifarnib in children and young adults (ages 1 to 21) whose cancer has returned or spread and has a specific change in the HRAS gene. The goal is to see if the drug can shrink tumors or stop them from growing. About 5 participants received the drug…

This study tests a drug called selpercatinib in children and young adults (ages 1 to 21) whose cancers have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. The trial is for patients with advanced solid…

This study tested the drug ensartinib in children and young adults (ages 1 to 21) whose advanced solid tumors, lymphoma, or related cancers had come back or stopped responding to treatment and had specific gene changes (ALK or ROS1). The goal was to see if the drug could shrink o…

This study tested a drug called erdafitinib in children and young adults (ages 1 to 21) whose cancers had spread, returned, or stopped responding to treatment. The drug targets tumors with specific changes in FGFR genes. The main goal was to see if the drug could shrink or stop t…

This early-phase trial tests a new approach for people with high-grade gliomas that have returned after prior treatment. Genetically modified neural stem cells are placed directly into the brain tumor to make it more sensitive to the chemotherapy drug irinotecan. The main goal is…

This study tests whether the drug pembrolizumab can shrink or stop the growth of a returning brain cancer called malignant glioma in people whose tumors have many genetic mutations. The drug works by activating the immune system to attack cancer cells. The study enrolled 27 adult…

This early-phase study tests a new immunotherapy for people with malignant glioma that has returned or not responded to standard treatment. Researchers take a patient's own T-cells (a type of immune cell), add a gene that helps them recognize and attack glioma cells, and infuse t…

This study tests a new type of MRI scan that looks at sodium and other signals in the brain to better understand tumors. It includes healthy volunteers and people with brain tumors (glioma). The goal is to improve how doctors detect and monitor these tumors, which could lead to b…

This study looks back at how 1,000 adults with recurrent malignant gliomas (a type of brain tumor) responded to chemotherapy and targeted therapy. The goal is to learn which treatments work best for different tumor types. No new treatments are given; the study simply collects dat…