RECURRENT EPENDYMOMA
Clinical trials for RECURRENT EPENDYMOMA explained in plain language.
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Precision drug ivosidenib tested in kids with tough IDH1 cancers
Disease control OngoingThis study tests a drug called ivosidenib in children and young adults (ages 1-21) whose cancers have a specific IDH1 gene change and have either returned or not responded to standard treatments. The goal is to see if the drug can shrink tumors. Only 3 participants were enrolled,…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:15 UTC
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Targeted drug shows promise for kids with rare, Hard-to-Treat cancers
Disease control OngoingThis study tests a drug called larotrectinib in children and young adults (ages 1 to 21) whose advanced or recurrent solid tumors, lymphoma, or histiocytic disorders have a specific genetic change called an NTRK fusion. The drug works by blocking enzymes that help cancer cells gr…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:12 UTC
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New hope for kids with rare cancers: targeted drug takes aim at HRAS gene
Disease control OngoingThis study tests a drug called tipifarnib in children and young adults (ages 1 to 21) whose cancer has returned or spread and has a specific change in the HRAS gene. The goal is to see if the drug can shrink tumors or stop them from growing. About 5 participants received the drug…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:12 UTC
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New hope for kids with tough brain cancers: targeted radiation shows promise
Disease control OngoingThis study tests a new treatment for children whose medulloblastoma or ependymoma has come back. It combines a specially designed antibody that delivers radiation directly into the brain fluid with standard chemotherapy drugs. The goal is to see if this approach can help children…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: Pediatric Brain Tumor Consortium • Aim: Disease control
Last updated May 17, 2026 04:11 UTC
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New targeted drug shows promise for kids with rare RET-Driven cancers
Disease control OngoingThis study tests a drug called selpercatinib in children and young adults (ages 1 to 21) whose cancers have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. The trial is for patients with advanced solid…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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Targeted drug shows promise for kids with Tough-to-Treat cancers
Disease control OngoingThis study tested the drug ensartinib in children and young adults (ages 1 to 21) whose advanced solid tumors, lymphoma, or related cancers had come back or stopped responding to treatment and had specific gene changes (ALK or ROS1). The goal was to see if the drug could shrink o…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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Promising brain cancer drug combo study pulled before it started
Disease control TerminatedThis study aimed to test the safety of giving a combination of drugs (nivolumab plus either methotrexate or 5-azacytidine) directly into the fluid-filled spaces of the brain for people with recurrent brain tumors like medulloblastoma and ependymoma. The goal was to see if this di…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE1 • Sponsor: Jeffrey Treiber • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Gene test trial aims to personalize cancer care for kids
Knowledge-focused OngoingThis study screens children and young adults (ages 1-21) with advanced solid tumors, lymphomas, or related disorders that have not responded to standard therapy. Researchers analyze the genetic makeup of each patient's tumor to find specific mutations that can be targeted by cert…
Matched conditions: RECURRENT EPENDYMOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 17, 2026 04:26 UTC