Promising brain cancer drug combo study pulled before it started

NCT ID NCT06466798

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 28 times

Summary

This study aimed to test the safety of giving a combination of drugs (nivolumab plus either methotrexate or 5-azacytidine) directly into the fluid-filled spaces of the brain for people with recurrent brain tumors like medulloblastoma and ependymoma. The goal was to see if this direct delivery method could be safer and more effective than standard treatments. However, the study was withdrawn before enrolling any participants, so no results are available.

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