REBOUND PAIN
Clinical trials for REBOUND PAIN explained in plain language.
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New painkiller may prevent sudden severe pain after shoulder surgery
Symptom relief CompletedThis study tested whether a long-acting form of the painkiller bupivacaine (liposomal bupivacaine) could prevent the sudden, severe pain that often occurs after a shoulder nerve block wears off. 100 adults having shoulder arthroscopy were randomly assigned to receive either lipos…
Matched conditions: REBOUND PAIN
Phase: PHASE4 • Sponsor: Liu Jiuhong • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Wrist surgery pain breakthrough? lower anesthetic dose may ease rebound pain
Symptom relief CompletedThis study looked at 80 adults having wrist fracture surgery to see if a lower concentration of the local anesthetic ropivacaine (3.75 mg/ml vs. 7.5 mg/ml) in a nerve block affects the severity of pain when the block wears off. Participants were randomly assigned to one of the tw…
Matched conditions: REBOUND PAIN
Phase: PHASE4 • Sponsor: Oslo University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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Knee replacement patients: when the nerve block wears off, severe pain may return
Knowledge-focused CompletedThis study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pa…
Matched conditions: REBOUND PAIN
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Heartbeat clues may forecast sudden Post-Surgery pain
Knowledge-focused CompletedThis study looked at whether heart rate variability (HRV) can predict rebound pain after total knee replacement. Rebound pain is a sudden, intense pain that can occur when nerve blocks wear off. Researchers measured HRV before and after surgery in 110 patients and tracked their p…
Matched conditions: REBOUND PAIN
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC