New painkiller may prevent sudden severe pain after shoulder surgery
NCT ID NCT07196631
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether a long-acting form of the painkiller bupivacaine (liposomal bupivacaine) could prevent the sudden, severe pain that often occurs after a shoulder nerve block wears off. 100 adults having shoulder arthroscopy were randomly assigned to receive either liposomal bupivacaine or the standard drug ropivacaine. The main goal was to see if liposomal bupivacaine reduced the chance of this 'rebound pain' in the first 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal bupivacaine
What this could lead to
If it works, this could provide a longer-lasting pain block after shoulder surgery, reducing the sudden severe pain that often occurs when the initial anesthetic wears off.
What could go wrong
This is a small, completed phase 4 trial with only 100 participants. Previous studies have shown mixed results, so the benefit may be modest or not clinically significant.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China