PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for PROGNOSTIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Experimental cocktail aims to turn tumors against themselves
Disease control OngoingThis early-stage study tests whether a mix of immune-boosting drugs and targeted radiation can help the body fight advanced solid tumors that cannot be removed by surgery. About 14 adults with certain types of skin cancer, sarcoma, or breast cancer will receive the treatment dire…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New targeted therapy combo shows promise for HER2+ breast cancer
Disease control OngoingThis study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab, with or without fulvestrant) for HER2-positive breast cancer. In the first part, it looks at safety in patients whose cancer has spread. In the second part, it compares these drugs to standard c…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Smart drug targets breast cancer in the brain
Disease control OngoingThis phase II trial tests a drug called sacituzumab govitecan in 44 patients with HER2-negative breast cancer that has spread to the brain. The drug is a targeted antibody that delivers chemotherapy directly to cancer cells. The goal is to see if it can shrink brain tumors or slo…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Cancer-Killing virus trial launches for Hard-to-Treat breast cancer
Disease control OngoingThis early-phase trial tests a new treatment for metastatic triple-negative breast cancer, a type that has spread and is hard to treat. The treatment uses a specially designed virus that is injected directly into tumors to infect and destroy cancer cells. The main goal is to find…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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New drug combo targets BRCA cancers in early trial
Disease control OngoingThis early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New scan could improve how we monitor bone metastases in breast cancer
Knowledge-focused OngoingThis phase 2 trial is testing whether a special type of PET/CT scan (FDG-PET/CT) can better measure how breast cancer that has spread to the bones responds to treatment. The study involves 138 participants with hormone receptor-positive metastatic breast cancer that is mostly in …
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Blood test could track breast cancer in real time
Knowledge-focused TerminatedThis study looks at whether regular blood tests can detect changes in stage IV breast cancer during treatment. Researchers will collect blood samples from 150 adults with metastatic breast cancer and analyze them for tumor DNA. The goal is to see if these tests can spot when the …
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Video education aims to demystify cancer genomic testing
Knowledge-focused OngoingThis study tests whether watching a short video can improve understanding of tumor genomic testing in 243 adults with metastatic cancer. Participants watch the video and then answer questions to measure their knowledge. The goal is to see if this simple tool helps patients better…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Blood test may help cancer patients avoid nerve damage from chemo
Knowledge-focused TerminatedThis pilot study aims to see if doctors can consistently measure paclitaxel levels in the blood of cancer patients receiving the drug. The goal is to eventually adjust doses to give enough chemo to fight cancer while reducing the common side effect of nerve damage. The study invo…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Gene test may guide breast cancer therapy choices
Knowledge-focused OngoingThis study looks at whether a genetic test on tumor samples can predict how well HER2-negative breast cancer will respond to standard treatments like chemotherapy or hormone therapy. About 1,100 people with stage I-III breast cancer are taking part. The goal is to see if this tes…
Matched conditions: PROGNOSTIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC