PHARMACODYNAMICS

This study compares a new rapid-acting insulin (I004) to the approved NovoLog in 60 healthy adults. Researchers measure how fast the insulin enters the blood and how well it controls blood sugar using a special clamp technique. The goal is to show the two insulins work the same, …

This early-phase trial tested the safety of a new drug called BB-025, designed to reverse the effects of another experimental drug, BB-031. 72 healthy volunteers received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The main goal was to check…

This study tested whether a new rapid-acting insulin (called I004) works the same as the approved insulin NovoLog. Sixty-nine healthy volunteers each received a single dose of both insulins at different times, and researchers measured how quickly the insulin entered the blood and…

This study tested how well a computer model predicts anesthesia depth compared to actual brain monitors. Seventy adults having elective surgery were split into two groups based on how they received anesthesia (slow vs. fast induction). The goal was to see if the model's predictio…

This completed study tested single doses of kratom in 40 healthy adults who have used opioids recreationally. Researchers measured safety, side effects, and how the body processes kratom. The goal was to gather basic information, not to treat any condition.