PELVIC ORGAN PROLAPSE (POP)

This study compares two common surgeries for uterine prolapse: the Manchester procedure and vaginal hysterectomy. About 426 women with symptomatic prolapse will be randomly assigned to one surgery and followed for up to 10 years. The main goal is to see which surgery has better s…

This study tests whether injecting poly-L-lactic acid (PLLA), an FDA-approved skin stimulant, into the vagina can strengthen tissue and treat a type of pelvic organ prolapse called cystocele (a bladder bulge into the vagina). The trial will compare PLLA injections to a placebo in…

This study compares two types of mesh surgery for women with pelvic organ prolapse (when organs slip out of place). One approach uses vaginal mesh, the other uses robotic-assisted abdominal mesh. Researchers want to see if vaginal mesh works just as well and is as safe as the rob…

This study tests if using an energy-based surgical device (LigaSure) to remove the fallopian tubes and ovaries during vaginal hysterectomy is safer and more effective than the standard knot-and-cut method. About 70 women with pelvic organ prolapse will take part. The goal is to s…

This study tests whether a numbing injection (paracervical block) given during vNOTES surgery can lower pain after the procedure. About 58 women having surgery for pelvic organ prolapse will be randomly assigned to receive either the numbing medicine or a placebo. The main goal i…

This study follows 288 women recovering from pelvic organ prolapse surgery. Participants wear a wrist accelerometer and answer a daily recovery questionnaire. Some receive routine post-op instructions, others get an exercise-focused plan. The goal is to see which group feels "mos…

This study follows 380 women for a year after vaginal childbirth to see how pelvic floor muscles and tissues recover. It also tests whether early, personalized pelvic floor muscle training can improve symptoms like urine leakage and pelvic organ prolapse compared to standard care…