Pediatric low-grade glioma
Clinical trials for Pediatric low-grade glioma explained in plain language.
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Can a targeted pill outperform chemotherapy for childhood brain tumors?
Disease control Recruiting nowThis trial tests whether a daily oral drug called trametinib can better control low-grade gliomas in children and young adults compared to standard weekly vinblastine chemotherapy. The study focuses on patients whose tumors do not have certain genetic changes (BRAF V600 mutation)…
Matched conditions: PEDIATRIC LOW-GRADE GLIOMA
Phase 2 • Sponsor: University Hospital, Strasbourg, France • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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New combo therapy hopes to tackle childhood brain tumors
Disease control Recruiting nowThis study tests a combination of two drugs, mirdametinib (taken by mouth) and vinblastine (given through a vein), in children and young adults with a type of brain tumor called low-grade glioma that has a specific genetic change (MAPK pathway activation). The trial has three par…
Matched conditions: PEDIATRIC LOW-GRADE GLIOMA
Phase 1/2 • Sponsor: St. Justine's Hospital • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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New drug cocktail aims to outsmart childhood brain tumors
Disease control Recruiting nowThis pilot study tests whether combining targeted therapy (MAPK inhibitors like trametinib and dabrafenib) with an immunotherapy drug (nivolumab) can safely and effectively treat children with BRAF-altered gliomas, a type of brain tumor. The study includes children with low-grade…
Matched conditions: PEDIATRIC LOW-GRADE GLIOMA
Phase 1/2 • Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC