New combo therapy hopes to tackle childhood brain tumors
NCT ID NCT06666348
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of two drugs, mirdametinib (taken by mouth) and vinblastine (given through a vein), in children and young adults with a type of brain tumor called low-grade glioma that has a specific genetic change (MAPK pathway activation). The trial has three parts: first finding the safest dose, then treating participants for about a year, and finally following them for three years. Up to 50 people aged 2 to 25 will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mirdametinib and vinblastine
- What this could lead to
- If this works, it could offer a new combination treatment for children with low-grade glioma that targets the MAPK pathway, potentially improving tumor control.
- What could go wrong
- This is an early phase 1/2 trial with only 50 participants, so the combination may prove too toxic or ineffective. The results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, T3B 6A8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Sainte-Justine
RECRUITINGMontreal, Quebec, H3T 1C5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Québec - Université Laval
RECRUITINGQuébec, Quebec, G1V 4G2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Sherbrooke
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital, London Health Sciences Centre
RECRUITINGLondon, Ontario, N6A5W9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Childrens and Womens Health Centre of British Columbia - British Columbia Childrens Hospital
RECRUITINGVancouver, British Columbia, V6H 3V4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stollery Children's Hospital
RECRUITINGEdmonton, Alberta, T6G 2E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Hospital for Sick Children
RECRUITINGToronto, Ontario, M5G 1E8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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