METASTATIC RECTAL ADENOCARCINOMA
Clinical trials for METASTATIC RECTAL ADENOCARCINOMA explained in plain language.
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New hope for hard-to-treat colorectal cancer: drug duo targets tumor defenses
Disease control OngoingThis study tests a combination of two drugs—SX-682 and nivolumab—in people with a specific type of advanced colorectal cancer (RAS-mutated, MSS) that has spread or can't be removed. The goal is to see if the combination is safe and can shrink tumors or slow their growth. About 51…
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 06:50 UTC
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Triple therapy offers new hope for Hard-to-Treat colorectal cancer
Disease control OngoingThis study tests a combination of two targeted drugs (encorafenib and cetuximab) plus an immunotherapy drug (nivolumab) in people with advanced colorectal cancer that has a specific BRAF mutation and is stable (not MSI-high). The goal is to see if this triple therapy can shrink t…
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 06:49 UTC
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New hope for tough-to-treat colon cancer? drug cocktail enters human trials
Disease control OngoingThis early-stage trial tests a combination of chemotherapy (FOLFOX), a blood-vessel blocker (bevacizumab), and two immunotherapy drugs (botensilimab and balstilimab) in 20 people with a type of advanced colorectal cancer called MSS that has spread. The goal is to see if this mix …
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 17, 2026 06:48 UTC
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New drug cocktail shows promise for Tough-to-Treat colorectal cancer
Disease control OngoingThis study tests whether adding two targeted drugs (LY3214996 and abemaciclib) to the standard drug cetuximab can shrink tumors or slow cancer growth in people with advanced colorectal cancer that no longer responds to cetuximab alone. About 46 adults with metastatic or inoperabl…
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 11, 2026 20:52 UTC
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Immunotherapy boost may tame tough colorectal cancer
Disease control OngoingThis study is for people with advanced colorectal cancer that has a specific genetic change (BRAF V600E) and has not responded to prior treatment. It compares the usual two-drug therapy (encorafenib and cetuximab) against the same two drugs plus an immunotherapy drug called nivol…
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 04, 2026 16:19 UTC
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Blood tests could unlock secrets of rectal cancer
Knowledge-focused OngoingThis study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these "circulating tumor elements" can tell us how the cancer responds to standard treatment. They will also compare results from cancer patients …
Matched conditions: METASTATIC RECTAL ADENOCARCINOMA
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 01, 2026 15:57 UTC