MELANOMA OF UNKNOWN PRIMARY
Clinical trials for MELANOMA OF UNKNOWN PRIMARY explained in plain language.
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Can a vaccine keep melanoma from coming back? large trial tests immune boosters
Disease control CompletedThis phase 3 trial tested whether a yeast-derived immune stimulant (GM-CSF) and a peptide vaccine, alone or together, could prevent melanoma from returning after surgery. 815 patients with no visible cancer after complete surgical removal of advanced melanoma were randomly assign…
Matched conditions: MELANOMA OF UNKNOWN PRIMARY
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Bone drug may supercharge immunotherapy against tough melanoma
Disease control CompletedThis study tested whether adding denosumab (a bone-strengthening drug) to standard immunotherapy (pembrolizumab or nivolumab) could help control advanced melanoma that has spread. Researchers enrolled 25 adults with stage III or IV melanoma who had not received prior immunotherap…
Matched conditions: MELANOMA OF UNKNOWN PRIMARY
Phase: PHASE2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New combo therapy shows promise for brain metastases
Disease control CompletedThis early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…
Matched conditions: MELANOMA OF UNKNOWN PRIMARY
Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC