LOCALLY ADVANCED RECTAL CARCINOMA
Clinical trials for LOCALLY ADVANCED RECTAL CARCINOMA explained in plain language.
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Less cutting, same cure? new trial tests smaller surgery for rectal cancer
Disease control OngoingThis study tests whether surgeons can safely remove less tissue during surgery for upper rectal cancer after patients have received pre-surgery therapy. About 874 adults with locally advanced rectal cancer will be randomly assigned to either standard or reduced surgical margins. …
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase: NA • Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Three-Drug chemo may let some rectal cancer patients skip surgery
Disease control OngoingThis phase II trial compares a three-drug chemotherapy combination (FOLFIRINOX) against standard two-drug combos (FOLFOX or CAPOX) in 783 patients with locally advanced rectal cancer. The goal is to see if the stronger regimen leads to a complete disappearance of the tumor, poten…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 26, 2026 15:05 UTC
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New scan could sharpen view of rectal cancer during treatment
Diagnosis OngoingThis early-phase trial tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to highlight rectal cancer cells. The goal is to see if this scan can show tumor extent and response more accurately than standard imaging before and after chemotherapy and radiation. About …
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase: EARLY_PHASE1 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated Jun 27, 2026 13:05 UTC
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Intermittent fasting tested to ease radiation side effects in cancer patients
Symptom relief OngoingThis phase II trial tests whether time-restricted eating (intermittent fasting) can reduce side effects from radiation or chemoradiation in people with prostate, cervical, or rectal cancers. About 49 participants will either follow a time-restricted eating plan or receive standar…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Exercise before and during radiotherapy: a new hope for rectal cancer?
Knowledge-focused TerminatedThis study planned to test if a 7-week program of aerobic and resistance exercise is feasible for people with locally advanced rectal cancer undergoing short-course radiotherapy. It aimed to recruit 30 patients and track how many joined, attended sessions, and stayed in the study…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase: NA • Sponsor: University of Hull • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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New study aims to predict who can skip surgery for rectal cancer
Knowledge-focused OngoingThis pilot study is testing whether regular MRI scans and blood tests can accurately track how rectal cancer responds to pre-surgery treatment. The goal is to develop a way to predict complete remission without needing surgery. Forty adults with locally advanced rectal cancer wil…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Sponsor: Jena University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:25 UTC