INFLAMMATORY DISEASE

This study tests whether analyzing a person's DNA and RNA can help doctors choose the right targeted therapy for hard-to-classify inflammatory diseases affecting at least two organs (including skin). Researchers will enroll 32 adults and check if the treatment improves symptoms a…

This study tests whether a comprehensive treatment can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease caused by inflammation. About 39 adults who have already had heart procedures like stents or bypass surgery will receive…

This study is testing a new radioactive tracer called 68Ga-FAPI46 that lights up on PET/CT scans in areas of inflammation and scarring. Researchers want to see if it can better detect and monitor chronic diseases like rheumatoid arthritis, liver fibrosis, and lupus. About 390 adu…

This study looks for new genes and biological clues in 300 people with rare autoinflammatory diseases (SAIDs). Researchers will use advanced genetic testing and blood analysis to find disease-causing mutations and unique immune patterns. The goal is to better understand these con…

This study follows 120 adults with coronary artery disease and signs of chronic inflammation to understand their symptoms, current treatments, and health outcomes over time. Researchers will track major heart events like heart attacks, need for procedures, or death. The goal is t…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Researchers will analyze blood samples from 200 volunteers to measure molecules that help resolve inflammation. The goal is to better understand why some people de…

This study looks at why some people with heart disease get worse much faster due to inflammation. Researchers will compare 20 patients with inflammation-related rapid coronary artery disease to 10 patients with typical disease. The goal is to find patterns in their health history…

This study aims to better understand heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect medical information, images, and samples from up to 5,000 participants, including healthy volunteers and family members. The goal is to …

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory diseases like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood over time to compare short-term and long-term use. The goal i…