HYPERTROPHIC CARDIOMYOPATHY (HCM)
Clinical trials for HYPERTROPHIC CARDIOMYOPATHY (HCM) explained in plain language.
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Experimental pill aims to ease thick heart muscle symptoms
Disease control Not yet recruitingThis phase 2 trial tests an oral drug called Aom0304 in adults with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The study includes people with both obstructive and non-obstructive forms. Participants receive different doses of Aom0304 for …
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Phase: PHASE2 • Sponsor: Amckaus PTY LTD. • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New drug targets Hard-to-Treat heart condition
Disease control Not yet recruitingThis study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle or tip of the heart's main pumping chamber. The goal is to see if mavacamten can reduce the pressure difference across the blockage a…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Phase: PHASE4 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Massive HCM database aims to unlock better heart care
Knowledge-focused Not yet recruitingThis study will collect health information from 3000 people with hypertrophic cardiomyopathy (HCM) across multiple hospitals in China. The goal is to build a comprehensive database to understand how the disease is currently diagnosed and treated, and to identify factors that affe…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: Xijing Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Heart rhythm mystery: study seeks clues to AF in Thick-Hearted patients
Knowledge-focused Not yet recruitingThis study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: Guy's and St Thomas' NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Gene secrets could explain why heart drug works for some, not others
Knowledge-focused Not yet recruitingThis study aims to find out why the heart medication mavacamten works better for some people with hypertrophic cardiomyopathy (a condition where the heart muscle is too thick) than for others. Researchers will look at participants' genes, including the specific gene causing their…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: University of Manchester • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Heart energy boost? MRI study tests new drug in thickened heart muscle
Knowledge-focused Not yet recruitingThis study looks at whether a new medication (mavacamten) can improve the energy levels of the heart muscle in people with obstructive hypertrophic cardiomyopathy, a condition where the heart wall thickens and blocks blood flow. Researchers will use a special MRI scan to measure …
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: University of Manchester • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC