HYPERCORTISOLISM
Clinical trials for HYPERCORTISOLISM explained in plain language.
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Drug metyrapone shows promise for Cushing's patients who Can't have surgery
Disease control CompletedThis study tested the drug metyrapone in 20 people with mild Cushing's syndrome who were not candidates for surgery. Over 24 weeks, researchers measured changes in blood pressure, blood sugar, cholesterol, bone health, and mental health. The goal was to see if metyrapone could he…
Matched conditions: HYPERCORTISOLISM
Sponsor: Istituto Auxologico Italiano • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New drug aims to tame cortisol overload from adrenal tumors
Disease control CompletedThis Phase 3 trial tested a drug called relacorilant in 137 people with hypercortisolism caused by adrenal adenomas or hyperplasia. The goal was to see if it could improve blood sugar control and lower high blood pressure. Participants received either relacorilant or a placebo fo…
Matched conditions: HYPERCORTISOLISM
Phase: PHASE3 • Sponsor: Corcept Therapeutics • Aim: Disease control
Last updated Jun 26, 2026 14:09 UTC
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Could a simple saliva test replace blood draws for cortisol screening?
Diagnosis CompletedThis study looked at whether a saliva test can accurately measure cortisol levels after a dexamethasone suppression test, compared to the standard blood test. Researchers studied about 100 patients with adrenal incidentalomas (non-cancerous growths on the adrenal gland) and 100 h…
Matched conditions: HYPERCORTISOLISM
Sponsor: Rigshospitalet, Denmark • Aim: Diagnosis
Last updated Jun 27, 2026 08:12 UTC
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Hidden hormone link in stubborn high blood pressure revealed
Knowledge-focused CompletedThis study looked at over 1,100 adults in the US whose high blood pressure stays high despite taking multiple medications. Researchers checked if these people also have a hormone condition called endogenous hypercortisolism, where the body makes too much cortisol. Participants ga…
Matched conditions: HYPERCORTISOLISM
Sponsor: Corcept Therapeutics • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC