HIGH GRADE GLIOMAS
Clinical trials for HIGH GRADE GLIOMAS explained in plain language.
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Sound waves open brain barrier to deliver cancer drug in kids
Disease control Not yet recruitingThis early-stage trial tests whether using focused ultrasound with microbubbles can temporarily open the blood-brain barrier, allowing the immunotherapy drug nivolumab to reach brain tumors more effectively. It includes 30 children and young adults with relapsed diffuse midline g…
Matched conditions: HIGH GRADE GLIOMAS
Phase: PHASE1 • Sponsor: Children's National Research Institute • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Virus and radiation combo takes on childhood brain cancer
Disease control Not yet recruitingThis study tests a virus called G207 combined with a small dose of radiation in children whose high-grade glioma has come back or is growing. The goal is to see if the treatment is safe and helps control the tumor. About 38 children will take part.
Matched conditions: HIGH GRADE GLIOMAS
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for kids with tough brain cancers: experimental drug trial launches
Disease control Not yet recruitingThis early-stage study tests an experimental drug called gallium maltolate in 15 children whose high-grade glioma or atypical teratoid rhabdoid tumor has returned or not responded to treatment. The main goals are to find safe doses and understand side effects. Everyone receives t…
Matched conditions: HIGH GRADE GLIOMAS
Phase: PHASE1 • Sponsor: Sarah Rumler • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Oxygen-Enhanced MRI could sharpen radiotherapy for deadly brain cancers
Diagnosis Not yet recruitingThis study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…
Matched conditions: HIGH GRADE GLIOMAS
Phase: NA • Sponsor: The Leeds Teaching Hospitals NHS Trust • Aim: Diagnosis
Last updated Jul 02, 2026 00:00 UTC
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Brain tumor study aims to clear up scans by shifting chemo timing
Knowledge-focused Not yet recruitingThis study tests giving chemotherapy before radiation for people with high-grade gliomas, a type of aggressive brain tumor. The goal is to see if this approach works well and makes MRI scans easier to read, since radiation can change how the brain looks. About 70 adults aged 18-8…
Matched conditions: HIGH GRADE GLIOMAS
Phase: PHASE2 • Sponsor: The Cooper Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC